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  • Second sialic acid binding site in Newcastle Disease virus hemagglutinin-neuraminidase: implications for fusion

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    Author(s)
    Zaitsev, V
    von Itzstein, M
    Groves, D
    Kiefel, M
    Takimoto, T
    Portner, A
    Taylor, G
    Griffith University Author(s)
    von Itzstein, Mark
    Kiefel, Milton
    Year published
    2004
    Metadata
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    Abstract
    Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell ...
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    Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.
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    Journal Title
    Journal of Virology
    Volume
    78
    Issue
    7
    DOI
    https://doi.org/10.1128/JVI.78.7.3733-3741.2004
    Copyright Statement
    © 2004 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological Sciences
    Agricultural and Veterinary Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/5051
    Collection
    • Journal articles

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