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dc.contributor.authorZaitsev, V
dc.contributor.authorvon Itzstein, M
dc.contributor.authorGroves, D
dc.contributor.authorKiefel, M
dc.contributor.authorTakimoto, T
dc.contributor.authorPortner, A
dc.contributor.authorTaylor, G
dc.contributor.editorThomas E Shenk, Lynn W Enquist
dc.date.accessioned2017-09-06T05:24:10Z
dc.date.available2017-09-06T05:24:10Z
dc.date.issued2004
dc.date.modified2009-10-19T05:23:54Z
dc.identifier.issn0022-538X
dc.identifier.doi10.1128/JVI.78.7.3733-3741.2004
dc.identifier.urihttp://hdl.handle.net/10072/5051
dc.description.abstractParamyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUSA
dc.relation.ispartofpagefrom3733
dc.relation.ispartofpageto3741
dc.relation.ispartofeditionApril
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Virology
dc.relation.ispartofvolume78
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleSecond sialic acid binding site in Newcastle Disease virus hemagglutinin-neuraminidase: implications for fusion
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPublished
gro.rights.copyright© 2004 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2004
gro.hasfulltextFull Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorKiefel, Milton


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