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dc.contributor.authorGerardy-Schahn, Ritaen_US
dc.contributor.authorJacob, Uween_US
dc.contributor.authorK. Muenster-Kuehnel, Anjaen_US
dc.contributor.authorKrapp, Stephanen_US
dc.contributor.authorRitz-Sedlacek, Valentinaen_US
dc.contributor.authorTiralongo, Joeen_US
dc.contributor.authorWeinhold, Birgiten_US
dc.date.accessioned2017-04-04T19:12:06Z
dc.date.available2017-04-04T19:12:06Z
dc.date.issued2004en_US
dc.date.modified2009-08-26T07:04:33Z
dc.identifier.issn09596658en_US
dc.identifier.doi10.1093/glycob/cwh113en_AU
dc.identifier.urihttp://hdl.handle.net/10072/5052
dc.description.abstractActivation of sugars into nucleotide sugars is critical for their entry into biosynthetic pathways. In eukaryotic cells, the activation of the acidic nine-carbon sugar sialic acid to CMP-sialic acid takes place in the cell nucleus, whereas all other nucleotide sugars are made in the cytoplasm. Molecular cloning of vertebrate CMP-sialic acid synthetases confirmed the nuclear localization and introduced new molecular tools for directly exploring the functional mechanisms of the enzymes, as well as the physiological relevance of their nuclear transport. Although major advances have been made in understanding structure-function relationships and defining elements involved in the nuclear transport, the riddle surrounding the physiological relevance of nuclear localization awaits resolution.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent1279642 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://glycob.oxfordjournals.org/en_AU
dc.relation.ispartofpagefrom43Ren_US
dc.relation.ispartofpageto51Ren_US
dc.relation.ispartofissue10en_AU
dc.relation.ispartofjournalGlycobiologyen_US
dc.relation.ispartofvolume14en_US
dc.subject.fieldofresearchcode320302en_US
dc.subject.fieldofresearchcode270108en_US
dc.titleStructure and function of vertebrate CMP-sialic acid synthetaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Glycobiology following peer review. The definitive publisher-authenticated version Glycobiology 2004 14(10):43R-51R is available online at: http://dx.doi.org/10.1093/glycob/cwh113 .en_AU
gro.date.issued2004
gro.hasfulltextFull Text


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