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dc.contributor.authorTiralongo, J
dc.contributor.authorSchauer, R
dc.contributor.editorKen-ichi Kasai (Kanagawa)
dc.date.accessioned2018-07-24T03:41:54Z
dc.date.available2018-07-24T03:41:54Z
dc.date.issued2004
dc.date.modified2009-09-01T06:00:38Z
dc.identifier.issn0915-7352
dc.identifier.doidoi.org/10.4052/tigg.16.1
dc.identifier.urihttp://hdl.handle.net/10072/5053
dc.description.abstractNaturally occurring sialic acids can be O-acetylated at any one of four hydroxyl groups, located at position C-4, -7, -8, and -9. This modification, which is found in nearly all animals expressing sialic acids and certain bacteria, is known to be involved in regulating a variety of biological events. One of the more important processes that appear to be heavily influenced by O-acetylation is cancer development. The present review outlines some of the more recent advances towards understanding the role and regulation of sialic acid O-acetylation in human colorectal cancer, basalioma and melanoma. Even though great strides have been made towards identifying and characterising the biological role of O-acetylated sialic acids, detailed information concerning the transferase activity responsible for this modification remains vague. The 7(9)-O- and 4-O-specific acetyltransferases were identified in bovine and horse submandibular glands, respectively, over 30 years ago, however despite the efforts of a number of groups these enzymes have stubbornly escaped purification and cloning, remaining elusive. Here we will attempt to summarise the available data gathered over several decades, as well as detailing recent advances towards understanding the mechanism and regulation of this enigmatic enzyme.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherGakushin Publishing Co.
dc.publisher.placeJapan
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto15
dc.relation.ispartofissue87
dc.relation.ispartofjournalTrends in Glycoscience and Glycotechnology
dc.relation.ispartofvolume16
dc.subject.fieldofresearchcode320302
dc.titleThe Enigma of Enzymatic Sialic Acid O-Acetylation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© 2004 Forum: Carbohydrates Coming of Age (FCCA). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2004
gro.hasfulltextFull Text
gro.griffith.authorTiralongo, Joe


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