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  • Dysinosins B-D, Inhibitors of Factor VIIa and Thrombin from the Australian Sponge Lamellodysidea chlorea

    Author(s)
    Carroll, AR
    Buchanan, MS
    Edser, A
    Hyde, E
    Simpson, M
    Quinn, RJ
    Griffith University Author(s)
    Quinn, Ronald J.
    Carroll, Anthony R.
    Year published
    2004
    Metadata
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    Abstract
    Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.
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    Journal Title
    Journal of Natural Products
    Volume
    67
    Publisher URI
    http://pubs.acs.org/journal/jnprdf
    DOI
    https://doi.org/10.1021/np049968p
    Copyright Statement
    © 2004 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. TPlease use the hypertext link above to access the journal's website or contact the author for more information.
    Subject
    Chemical sciences
    Biological sciences
    Biomedical and clinical sciences
    History, heritage and archaeology
    Traditional, complementary and integrative medicine
    Publication URI
    http://hdl.handle.net/10072/5056
    Collection
    • Journal articles

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