Dysinosins B-D, Inhibitors of Factor VIIa and Thrombin from the Australian Sponge Lamellodysidea chlorea
Author(s)
Carroll, AR
Buchanan, MS
Edser, A
Hyde, E
Simpson, M
Quinn, RJ
Year published
2004
Metadata
Show full item recordAbstract
Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.
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Journal Title
Journal of Natural Products
Volume
67
Publisher URI
Copyright Statement
© 2004 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. TPlease use the hypertext link above to access the journal's website or contact the author for more information.
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
History, heritage and archaeology
Traditional, complementary and integrative medicine