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dc.contributor.authorWellard, R.en_US
dc.contributor.authorBriellmann, R.en_US
dc.contributor.authorWilson, Jennyen_US
dc.contributor.authorKalnins, R.en_US
dc.contributor.authorAnderson, D.en_US
dc.contributor.authorSederico, P.en_US
dc.contributor.authorFabinyi, D.en_US
dc.contributor.authorScheffer, I.en_US
dc.contributor.authorHarvey, A.en_US
dc.contributor.authorJackson, D.en_US
dc.date.accessioned2017-04-24T09:17:06Z
dc.date.available2017-04-24T09:17:06Z
dc.date.issued2004en_US
dc.date.modified2012-02-10T01:11:18Z
dc.identifier.issn00068950en_US
dc.identifier.doi10.1093/brain/awh157en_US
dc.identifier.urihttp://hdl.handle.net/10072/5063
dc.description.abstractThis study analyses the evolution of metabolite changes in an 8-year-old boy with focal Rasmussen encephalitis. Five MRI examinations, including magnetic resonance spectroscopy (MRS) were performed over 9 months. Following complex partial status, T2-weighted imaging showed transient dramatic signal increase in the left superior temporal gyrus and mesial temporal structures. Subsequent scans showed resolution of the swelling and signal normalization, with development of slight focal atrophy. MRS after status showed a reduction in N-acetylaspartate, total creatine and trimethylamines. Subsequent scans showed complete resolution of these metabolite abnormalities, followed later by development of further abnormal metabolite values. Lactate and glutamine/glutamate were elevated after status. After surgery, ex vivo high-field 1H and 31P MRS confirmed metabolite abnormalities (elevated choline and decreased aspartate, N-acetylaspartate, [1H]glutamate together with altered [31P]phospholipid ratios. These findings suggested active disease process in the anterior region of the excised superior temporal gyrus. We conclude that Rasmussen encephalitis is a combination of progressive encephalitic damage and fluctuating seizure effects, in which neuronal injury and recovery can occur. MRS measurements at a single time point should consider the fluctuating metabolite profile related to seizure activity.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent292080 bytes
dc.format.extent47882 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherOxford University Pressen_US
dc.publisher.placeOxforden_US
dc.publisher.urihttp://brain.oxfordjournals.org/en_US
dc.relation.ispartofpagefrom1302en_US
dc.relation.ispartofpageto1312en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalBrainen_US
dc.relation.ispartofvolume127en_US
dc.subject.fieldofresearchcode250302en_US
dc.titleLongitudinal study of MRS metabolites in Rasmussens encephalitisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Brain following peer review. The definitive publisher-authenticated version Brain (2004), 127, 1302-1312 is available online at: http://dx.doi.org/10.1093/brain/awh157en_US
gro.date.issued2004
gro.hasfulltextFull Text


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