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dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2012-05-08
dc.date.accessioned2017-03-01T22:57:00Z
dc.date.available2017-03-01T22:57:00Z
dc.date.issued2012
dc.date.modified2013-06-04T00:03:13Z
dc.identifier.issn2249-0159
dc.identifier.doi10.5530/pc.2012.2.13
dc.identifier.urihttp://hdl.handle.net/10072/50677
dc.description.abstractA collaboration bet\veen research groups in Philadelphia and Saint Louis has highlighted the potential of the green tea polyphenols epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in the treatment of the deaclly congenital disease hypcrinsulinism/hyperammoncmfa syndrome (J-IJ-IS). Individuals with HI-IS respond to the consumption of dietary protein by secreting high levels of insulin, resulting in dangerously low blood glucose levels. If left untreated, HHS may lead to death. Recently, HHS has been linked with loss of regulation of the enzyme glutamate dehydrogenase (GOH). The US group has shown that oral admisinsteration of ECG and EGCG can inhibit GOH, thus blocking HHS. This research also has more wide teaching applications in the treatment of other diseases. For example, it has also been shown that glioblastoma cells require an active GOH to survive, indicating the potential of ECG and EGCG- as lead products in the treatment of tumots.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.format.extent108992 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPharmacognosy Network Worldwide
dc.publisher.placeIndia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom81
dc.relation.ispartofpageto81
dc.relation.ispartofissue2
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume2
dc.rights.retentionY
dc.subject.fieldofresearchBiological Sciences not elsewhere classified
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode069999
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleGreen Tea in the Treatment of a Congenital Disease and Tumors
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dc.type.codec2
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.rights.copyright© 2012 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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