dc.contributor.author | Cock, Ian Edwin | |
dc.date.accessioned | 2012-05-08 | |
dc.date.accessioned | 2017-03-01T22:57:00Z | |
dc.date.available | 2017-03-01T22:57:00Z | |
dc.date.issued | 2012 | |
dc.date.modified | 2013-06-04T00:03:13Z | |
dc.identifier.issn | 2249-0159 | |
dc.identifier.doi | 10.5530/pc.2012.2.13 | |
dc.identifier.uri | http://hdl.handle.net/10072/50677 | |
dc.description.abstract | A collaboration bet\veen research groups in Philadelphia and Saint Louis has highlighted the potential of the green tea polyphenols epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) in the treatment of the deaclly congenital disease hypcrinsulinism/hyperammoncmfa syndrome (J-IJ-IS). Individuals with HI-IS respond to the consumption of dietary protein by secreting high levels of insulin, resulting in dangerously low blood glucose levels. If left untreated, HHS may lead to death. Recently, HHS has been linked with loss of regulation of the enzyme glutamate dehydrogenase (GOH). The US group has shown that oral admisinsteration of ECG and EGCG can inhibit GOH, thus blocking HHS. This research also has more wide teaching applications in the treatment of other diseases. For example, it has also been shown that glioblastoma cells require an active GOH to survive, indicating the potential of ECG and EGCG- as lead products in the treatment of tumots. | |
dc.description.peerreviewed | No | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 108992 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Pharmacognosy Network Worldwide | |
dc.publisher.place | India | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 81 | |
dc.relation.ispartofpageto | 81 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Pharmacognosy Communications | |
dc.relation.ispartofvolume | 2 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Biological Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Plant Biology | |
dc.subject.fieldofresearch | Pharmacology and Pharmaceutical Sciences | |
dc.subject.fieldofresearchcode | 069999 | |
dc.subject.fieldofresearchcode | 0607 | |
dc.subject.fieldofresearchcode | 1115 | |
dc.title | Green Tea in the Treatment of a Congenital Disease and Tumors | |
dc.type | Journal article | |
dc.type.description | C2 - Articles (Other) | |
dc.type.code | c2 | |
gro.faculty | Faculty of Science, Environment, Engineering and Technology | |
gro.rights.copyright | © 2012 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. | |
gro.date.issued | 2012 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Cock, Ian E. | |