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dc.contributor.authorNduhirabandi, F
dc.contributor.authordu Toit, EF
dc.contributor.authorLochner, A
dc.date.accessioned2017-05-03T15:31:46Z
dc.date.available2017-05-03T15:31:46Z
dc.date.issued2012
dc.date.modified2013-06-30T23:14:14Z
dc.identifier.issn1748-1708
dc.identifier.doi10.1111/j.1748-1716.2012.02410.x
dc.identifier.urihttp://hdl.handle.net/10072/50783
dc.description.abstractThe metabolic syndrome (MetS) is a cluster of metabolic abnormalities associated with increased risk for cardiovascular diseases. Apart from its powerful antioxidant properties, the pineal gland hormone melatonin has recently attracted the interest of various investigators as a multifunctional molecule. Melatonin has been shown to have beneficial effects in cardiovascular disorders including ischaemic heart disease and hypertension. However, its role in cardiovascular risk factors including obesity and other related metabolic abnormalities is not yet established, particularly in humans. New emerging data show that melatonin may play an important role in body weight regulation and energy metabolism. This review will address the role of melatonin in the MetS focusing on its effects in obesity, insulin resistance and leptin resistance. The overall findings suggest that melatonin should be exploited as a therapeutic tool to prevent or reverse the harmful effects of obesity and its related metabolic disorders.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent247273 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom209
dc.relation.ispartofpageto223
dc.relation.ispartofissue2
dc.relation.ispartofjournalActa Physiologica
dc.relation.ispartofvolume205
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchMedical physiology not elsewhere classified
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode320899
dc.titleMelatonin and the metabolic syndrome: A tool for effective therapy in obesity-associated abnormalities?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightAuthor Posting. Copyright 2012 The Authors. This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in Acta Physiologica, Volume 205, Issue 2, pages 209–223, http://dx.doi.org/10.1111/j.1748-1716.2012.02410.x.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorDu Toit, Eugene


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