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  • Vaccination Against Rheumatic Heart Disease: A Review of Current Research Strategies and Challenges

    Author
    Pandey, Manisha
    Batzloff, Michael
    Good, Michael
    Year published
    2012
    Metadata
    Show full item record
    Abstract
    Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are major health problems in many developing countries and Indigenous populations of developed countries. ARF and RHD are sequelae resulting from an infection of Streptococcus pyogenes. Despite advances in health care practices and technology, these diseases still pose major challenges in the communities where Streptococcus pyogenes is often endemic. Here we review and discuss the dynamic epidemiology of streptococcal infection and its associated diseases (ARF and RHD), with a focus on disease burden in temperate versus tropical regions, the tissue tropism of the ...
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    Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are major health problems in many developing countries and Indigenous populations of developed countries. ARF and RHD are sequelae resulting from an infection of Streptococcus pyogenes. Despite advances in health care practices and technology, these diseases still pose major challenges in the communities where Streptococcus pyogenes is often endemic. Here we review and discuss the dynamic epidemiology of streptococcal infection and its associated diseases (ARF and RHD), with a focus on disease burden in temperate versus tropical regions, the tissue tropism of the organism and the efforts towards vaccine development in relation to the available animal models.
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    Journal Title
    Current Infectious Disease Reports
    Volume
    14
    Issue
    4
    DOI
    https://doi.org/10.1007/s11908-012-0263-7
    Subject
    Bacteriology
    Publication URI
    http://hdl.handle.net/10072/50784
    Collection
    • Journal articles

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