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dc.contributor.authorPandey, Manisha
dc.contributor.authorBatzloff, Michael R
dc.contributor.authorGood, Michael F
dc.date.accessioned2017-05-03T14:27:07Z
dc.date.available2017-05-03T14:27:07Z
dc.date.issued2012
dc.date.modified2013-05-24T02:39:42Z
dc.identifier.issn1523-3847
dc.identifier.doi10.1007/s11908-012-0263-7
dc.identifier.urihttp://hdl.handle.net/10072/50784
dc.description.abstractAcute rheumatic fever (ARF) and rheumatic heart disease (RHD) are major health problems in many developing countries and Indigenous populations of developed countries. ARF and RHD are sequelae resulting from an infection of Streptococcus pyogenes. Despite advances in health care practices and technology, these diseases still pose major challenges in the communities where Streptococcus pyogenes is often endemic. Here we review and discuss the dynamic epidemiology of streptococcal infection and its associated diseases (ARF and RHD), with a focus on disease burden in temperate versus tropical regions, the tissue tropism of the organism and the efforts towards vaccine development in relation to the available animal models.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom381
dc.relation.ispartofpageto390
dc.relation.ispartofissue4
dc.relation.ispartofjournalCurrent Infectious Disease Reports
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchBacteriology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchEpidemiology
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode310701
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4202
dc.subject.fieldofresearchcode4206
dc.titleVaccination Against Rheumatic Heart Disease: A Review of Current Research Strategies and Challenges
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorPandey, Manisha
gro.griffith.authorGood, Michael F.


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