Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-clerodanes
Author(s)
Mirzayans, Paul Malek
Pouwer, Rebecca H.
Williams, Craig M.
V. Bernhardt, Paul
Griffith University Author(s)
Year published
2012
Metadata
Show full item recordAbstract
The 19-nor-clerodanes are compact, densely functionalized diterpenes based on a stereocentre-rich decalin scaffold. To date only a few examples of the 19-nor-clerodanes have been synthesized, hence new flexible strategies are required. We herein describe the stereocontrolled construction of the cis-hydroxy decalin core in a concise fashion.The 19-nor-clerodanes are compact, densely functionalized diterpenes based on a stereocentre-rich decalin scaffold. To date only a few examples of the 19-nor-clerodanes have been synthesized, hence new flexible strategies are required. We herein describe the stereocontrolled construction of the cis-hydroxy decalin core in a concise fashion.
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Journal Title
European Journal of Organic Chemistry
Volume
2012
Issue
8
Subject
Organic Chemical Synthesis
Medicinal and Biomolecular Chemistry
Organic Chemistry