dc.contributor.author | O'Gorman, Cullen | |
dc.contributor.author | Lucas, Robyn | |
dc.contributor.author | Taylor, Bruce | |
dc.date.accessioned | 2017-05-03T16:03:14Z | |
dc.date.available | 2017-05-03T16:03:14Z | |
dc.date.issued | 2012 | |
dc.date.modified | 2013-07-02T23:08:43Z | |
dc.identifier.issn | 14220067 | |
dc.identifier.doi | 10.3390/ijms130911718 | |
dc.identifier.uri | http://hdl.handle.net/10072/51383 | |
dc.description.abstract | Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system commonly affecting young adults. Pathologically, there are patches of inflammation (plaques) with demyelination of axons and oligodendrocyte loss. There is a global latitude gradient in MS prevalence, and incidence of MS is increasing (particularly in females). These changes suggest a major role for environmental factors in causation of disease. We have reviewed the evidence and potential mechanisms of action for three exposures: vitamin D, Epstein Barr virus and cigarette smoking. Recent advances supporting gene-environment interactions are reviewed. Further research is needed to establish mechanisms of causality in humans and to explore preventative strategies. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.format.extent | 302922 bytes | |
dc.format.mimetype | application/pdf | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | MDPIAG | |
dc.publisher.place | Switzerland | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 11718 | |
dc.relation.ispartofpageto | 11752 | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | International Journal of Molecular Sciences | |
dc.relation.ispartofvolume | 13 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearch | Genetics | |
dc.subject.fieldofresearch | Other biological sciences | |
dc.subject.fieldofresearchcode | 3499 | |
dc.subject.fieldofresearchcode | 3105 | |
dc.subject.fieldofresearchcode | 3199 | |
dc.title | Environmental Risk Factors for Multiple Sclerosis: A Review with a Focus on Molecular Mechanisms | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2012 MDPI (http://www.mdpi.org). The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version. | |
gro.date.issued | 2012 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | O'Gorman, Cullen | |