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dc.contributor.authorBensadoun, Rene-Jean
dc.contributor.authorNair, Raj
dc.date.accessioned2017-05-03T15:14:13Z
dc.date.available2017-05-03T15:14:13Z
dc.date.issued2012
dc.date.modified2013-06-14T00:30:24Z
dc.identifier.issn10408746
dc.identifier.doi10.1097/CCO.0b013e328352eaa3
dc.identifier.urihttp://hdl.handle.net/10072/51467
dc.description.abstractPurpose of review To discuss the promising state of the art low-level laser therapy (LLLT) for preventive and therapeutic usage in oral mucositis due to cancer therapy. Recent findings Photomedicine using LLLT is very effective with intraoral and extraoral devices in the management of oral mucositis, based on several studies including randomized control studies. A systematic review identified 33 relevant articles that were subjected to meta-analysis based on which laser parameters in routine practice are being defined. Meta-analysis showed that LLLT reduced risk of oral mucositis with relative risk (RR) 2.45 [confidence interval (CI) 1.85-3.18], reduced duration, severity of oral mucositis and reduced number of days with oral mucositis (4.38 days, P찮0009). RR was similar between the red (630-670 nm) and infrared (780-830 nm) LLLT. Pain-relieving effect based on the Cohen scale was at 1.22 (CI 0.19-2.25). Summary No adverse side effects of LLLT were reported; hence, we recommend red or infrared LLLT with diode output between 10-100mW, dose of 2-3 J/cm2/cm2 for prophylaxis and 4 J/cm2 (maximum limit) for therapeutic effect, application on single spot rather than scanning motion. Lesions must be evaluated by a trained clinician and therapy should be repeated daily or every other day or a minimum of three times per week until resolution. There is moderate-to-strong evidence in favor of LLLT at optimal doses as a well tolerated, relatively inexpensive intervention for cancer therapy-induced oral mucositis. It is envisaged that LLLT will soon become part of routine oral supportive care in cancer.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom363
dc.relation.ispartofpageto370
dc.relation.ispartofissue4
dc.relation.ispartofjournalCurrent Opinion in Oncology
dc.relation.ispartofvolume24
dc.rights.retentionY
dc.subject.fieldofresearchRadiation Therapy
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111208
dc.subject.fieldofresearchcode1112
dc.titleLow-level laser therapy in the prevention and treatment of cancer therapy-induced mucositis: 2012 state of the art based on literature review and meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorNair, Raj


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