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dc.contributor.authorEngwerda, Christian R
dc.contributor.authorGood, Michael F
dc.date.accessioned2017-05-03T15:04:54Z
dc.date.available2017-05-03T15:04:54Z
dc.date.issued2012
dc.date.modified2014-10-07T23:44:55Z
dc.identifier.issn0036-8075
dc.identifier.doi10.1126/science.1232439
dc.identifier.urihttp://hdl.handle.net/10072/51684
dc.description.abstractThe estimated 216 million cases of malaria in 2010 resulted in about 655,000 deaths, around 86% of which were children under the age of 5 (1), mainly in sub-Saharan Africa. Most of these deaths are caused by the protozoan parasite Plasmodium falciparum. Our poor understanding of innate resistance and the development of immunity to P. falciparum is an obstacle to developing vaccines and new therapeutics. The human body has numerous defenses to protect itself against severe forms of malaria. One such strategy, previously underappreciated, involves platelets-unnucleated fragments of megakaryocytes normally thought of as being critical solely to prevent hemorrhage. On page 1348 in this issue, McMorran et al. (2) reveal a mechanism by which platelets can recognize infected red blood cells and kill the parasite within (see the figure).
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1304
dc.relation.ispartofpageto1305
dc.relation.ispartofissue6112
dc.relation.ispartofjournalScience
dc.relation.ispartofvolume338
dc.rights.retentionY
dc.subject.fieldofresearchInfectious agents
dc.subject.fieldofresearchcode310702
dc.titlePlatelets kill the parasite within
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorGood, Michael F.


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