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  • Hypertonic Dextrose and Morrhuate Sodium Injections (Prolotherapy) for Lateral Epicondylosis (Tennis Elbow). Results of a Single-blind, Pilot-Level, Randomized Controlled Trial

    Author(s)
    Rabago, David
    Lee, Ken S
    Ryan, Michael
    Chourasia, Amrish O
    Sesto, Mary E
    Zgierska, Aleksandra
    Kijowski, Rick
    Grettie, Jessica
    Wilson, John
    Miller, Daniel
    Griffith University Author(s)
    Ryan, Michael
    Year published
    2013
    Metadata
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    Abstract
    Objective: Chronic lateral epicondylosis is common, debilitating, and often refractory. Prolotherapy (PrT) is an injection therapy for tendinopathy. The efficacy of two PrT solutions for chronic lateral epicondylosis was evaluated. Design: This study is a three-arm randomized controlled trial. Twenty-six adults (32 elbows) with chronic lateral epicondylosis for 3 mos or longer were randomized to ultrasound-guided PrT with dextrose solution, ultrasound-guided PrT with dextrose-morrhuate sodium solution, or watchful waiting (Bwait and see[). The primary outcome was the Patient-Rated Tennis Elbow Evaluation (100 points) at 4, ...
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    Objective: Chronic lateral epicondylosis is common, debilitating, and often refractory. Prolotherapy (PrT) is an injection therapy for tendinopathy. The efficacy of two PrT solutions for chronic lateral epicondylosis was evaluated. Design: This study is a three-arm randomized controlled trial. Twenty-six adults (32 elbows) with chronic lateral epicondylosis for 3 mos or longer were randomized to ultrasound-guided PrT with dextrose solution, ultrasound-guided PrT with dextrose-morrhuate sodium solution, or watchful waiting (Bwait and see[). The primary outcome was the Patient-Rated Tennis Elbow Evaluation (100 points) at 4, 8, and 16 wks (all groups) and at 32 wks (PrT groups). The secondary outcomes included pain-free grip strength and magnetic resonance imaging severity score. Results: The participants receiving PrT with dextrose and PrT with dextrosemorrhuate reported improved Patient-Rated Tennis Elbow Evaluation composite and subscale scores at 4, 8, and/or 16 wks compared with those in the wait-andsee group (P G 0.05). At 16 wks, compared with baseline, the PrT with dextrose and PrT with dextrose-morrhuate groups reported improved composite Patient- Rated Tennis Elbow Evaluation scores by a mean (SE) of 18.7 (9.6; 41.1%) and 17.5 (11.6; 53.5%) points, respectively. The grip strength of the participants receiving PrTwith dextrose exceeded that of the PrTwith dextrose-morrhuate and the wait and see at 8 and 16 wks (P G 0.05). There were no differences in magnetic resonance imaging scores. Satisfaction was high; there were no adverse events. Conclusions: PrT resulted in safe, significant improvement of elbow pain and function compared with baseline status and follow-up data and the wait-and-see control group. This pilot study suggests the need for a definitive trial.
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    Journal Title
    American Journal of Physical Medicine and Rehabilitation
    Volume
    92
    Issue
    7
    DOI
    https://doi.org/10.1097/PHM.0b013e31827d695f
    Subject
    Clinical sciences
    Traditional, complementary and integrative medicine not elsewhere classified
    Sports science and exercise
    Publication URI
    http://hdl.handle.net/10072/51706
    Collection
    • Journal articles

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