Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.
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Bioassay-guided isolation of the CH2Cl2/MeOH extract from the Australian sponge Iotrochota sp. resulted in the purification of two new N-cinnamoyl-amino acids, iotrochamides A (1) and B (2). The chemical structures of 1 and 2 were determined by 1D/2D NMR and MS data analyses. Compounds 1 and 2 were shown to inhibit Trypanosoma brucei brucei with IC50 values of 3.4 and 4.7 卬 respectively.
Bioorganic and Medicinal Chemistry Letters
Copyright 2012 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Biologically Active Molecules