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  • Cancer stem cell targeting: the next generation of cancer therapy and molecular imaging

    Author(s)
    Shigdar, S
    Lin, J
    Li, Y
    Yang, CJ
    Wei, M
    Zhu, Y
    Liu, H
    Duan, W
    Griffith University Author(s)
    Wei, Ming Q.
    Year published
    2012
    Metadata
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    Abstract
    Cancer stem cells (CSCs) have the capacity to generate the heterogeneous lineages of all cancer cells comprising a tumor and these populations of cells are likely to be more relevant in determining prognosis. However, these cells do not operate in isolation, but instead rely upon signals co-opted from their microenvironment, making the targeting and imaging of CSCs within a cancer mass a daunting task. A better understanding of the molecular cell biology underlying CSC pathology will facilitate the development of new therapeutic targets and novel strategies for the successful eradication of cancer. In addition, the continued ...
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    Cancer stem cells (CSCs) have the capacity to generate the heterogeneous lineages of all cancer cells comprising a tumor and these populations of cells are likely to be more relevant in determining prognosis. However, these cells do not operate in isolation, but instead rely upon signals co-opted from their microenvironment, making the targeting and imaging of CSCs within a cancer mass a daunting task. A better understanding of the molecular cell biology underlying CSC pathology will facilitate the development of new therapeutic targets and novel strategies for the successful eradication of cancer. In addition, the continued investigation of sensitive molecular-imaging modalities will enable more accurate staging, treatment planning and the ability to monitor the effectiveness of CSC-targeted therapies in vivo. In this review, we explore the possibilities and limitations of CSC-directed therapies and molecular imaging modalities.
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    Journal Title
    Therapeutic Delivery
    Volume
    3
    Issue
    2
    DOI
    https://doi.org/10.4155/tde.11.148
    Subject
    Biomedical engineering
    Medical biotechnology
    Cancer therapy (excl. chemotherapy and radiation therapy)
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/51753
    Collection
    • Journal articles

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