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dc.contributor.authorLe Couteur, David G
dc.contributor.authorMcLachlan, Andrew J
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorSimpson, Stephen J
dc.contributor.authorde Cabo, Rafael
dc.date.accessioned2017-05-03T11:15:21Z
dc.date.available2017-05-03T11:15:21Z
dc.date.issued2012
dc.date.modified2014-04-22T04:46:42Z
dc.identifier.issn1079-5006
dc.identifier.doi10.1093/gerona/glr095
dc.identifier.urihttp://hdl.handle.net/10072/51821
dc.description.abstractDespite remarkable technological advances in genetics and drug screening, the discovery of new pharmacotherapies has slowed and new approaches to drug development are needed. Research into the biology of aging is generating many novel targets for drug development that may delay all age-related diseases and be used long term by the entire population. Drugs that successfully delay the aging process will clearly become "blockbusters." To date, the most promising leads have come from studies of the cellular pathways mediating the longevity effects of caloric restriction (CR), particularly target of rapamycin and the sirtuins. Similar research into pathways governing other hormetic responses that influence aging is likely to yield even more targets. As aging becomes a more attractive target for drug development, there will be increasing demand to develop biomarkers of aging as surrogate outcomes for the testing of the effects of new agents on the aging process.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent223748 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom168
dc.relation.ispartofpageto174
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Gerontology: Series A
dc.relation.ispartofvolume67A
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and biomolecular chemistry not elsewhere classified
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode340499
dc.subject.fieldofresearchcode3202
dc.titleAging Biology and Novel Targets for Drug Discovery
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2012 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journals of Gerontology Series A following peer review. The definitive publisher-authenticated version, Aging Biology and Novel Targets for Drug Discovery, Journals of Gerontology Series A, Vol. 67A(2), 2012, pp. 168-174] is available online at: dx.doi.org/10.1093/gerona/glr095.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.


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