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dc.contributor.authorByrne, NM
dc.contributor.authorWood, RE
dc.contributor.authorSchulz, Y
dc.contributor.authorHills, Andrew
dc.date.accessioned2017-05-03T16:00:53Z
dc.date.available2017-05-03T16:00:53Z
dc.date.issued2012
dc.date.modified2013-06-25T00:23:35Z
dc.identifier.issn03070565
dc.identifier.doi10.1038/ijo.2012.109
dc.identifier.urihttp://hdl.handle.net/10072/51855
dc.description.abstractObjective: We investigated to what extent changes in metabolic rate and composition of weight loss explained the less-than-expected weight loss in obese men and women during a diet-plus-exercise intervention. Design: In all, 16 obese men and women (41Ṡyears; body mass index (BMI) 39ᶿkg?m-2) were investigated in energy balance before, after and twice during a 12-week very-low-energy diet(565-650?kcal per day) plus exercise (aerobic plus resistance training) intervention. The relative energy deficit (EDef) from baseline requirements was severe (74%-87%). Body composition was measured by deuterium dilution and dual energy X-ray absorptiometry, and resting metabolic rate (RMR) was measured by indirect calorimetry. Fat mass (FM) and fat-free mass (FFM) were converted into energy equivalents using constants 9.45?kcal per g FM and 1.13?kcal per g FFM. Predicted weight loss was calculated from the EDef using the '7700?kcal?kg-1 rule'. Results: Changes in weight (-18.6ᵮ0?kg), FM (-15.5ᴮ3?kg) and FFM (-3.1ᱮ9?kg) did not differ between genders. Measured weight loss was on average 67% of the predicted value, but ranged from 39% to 94%. Relative EDef was correlated with the decrease in RMR (R=0.70, P<0.01), and the decrease in RMR correlated with the difference between actual and expected weight loss (R=0.51, P<0.01). Changes in metabolic rate explained on average 67% of the less-than-expected weight loss, and variability in the proportion of weight lost as FM accounted for a further 5%. On average, after adjustment for changes in metabolic rate and body composition of weight lost, actual weight loss reached 90% of the predicted values. Conclusion: Although weight loss was 33% lower than predicted at baseline from standard energy equivalents, the majority of this differential was explained by physiological variables. Although lower-than-expected weight loss is often attributed to incomplete adherence to prescribed interventions, the influence of baseline calculation errors and metabolic downregulation should not be discounted.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMacmillan Publishers
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1472
dc.relation.ispartofpageto1478
dc.relation.ispartofjournalInternational Journal of Obesity
dc.relation.ispartofvolume36
dc.rights.retentionY
dc.subject.fieldofresearchExercise Physiology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchEducation
dc.subject.fieldofresearchcode110602
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode13
dc.titleDoes metabolic compensation explain the majority of less-than-expected weight loss in obese adults during a short-term severe diet and exercise intervention?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorHills, Andrew


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