dc.contributor.author | Byrne, NM | |
dc.contributor.author | Wood, RE | |
dc.contributor.author | Schulz, Y | |
dc.contributor.author | Hills, Andrew | |
dc.date.accessioned | 2017-05-03T16:00:53Z | |
dc.date.available | 2017-05-03T16:00:53Z | |
dc.date.issued | 2012 | |
dc.date.modified | 2013-06-25T00:23:35Z | |
dc.identifier.issn | 03070565 | |
dc.identifier.doi | 10.1038/ijo.2012.109 | |
dc.identifier.uri | http://hdl.handle.net/10072/51855 | |
dc.description.abstract | Objective: We investigated to what extent changes in metabolic rate and composition of weight loss explained the less-than-expected weight loss in obese men and women during a diet-plus-exercise intervention. Design: In all, 16 obese men and women (41Ṡyears; body mass index (BMI) 39ᶿkg?m-2) were investigated in energy balance before, after and twice during a 12-week very-low-energy diet(565-650?kcal per day) plus exercise (aerobic plus resistance training) intervention. The relative energy deficit (EDef) from baseline requirements was severe (74%-87%). Body composition was measured by deuterium dilution and dual energy X-ray absorptiometry, and resting metabolic rate (RMR) was measured by indirect calorimetry. Fat mass (FM) and fat-free mass (FFM) were converted into energy equivalents using constants 9.45?kcal per g FM and 1.13?kcal per g FFM. Predicted weight loss was calculated from the EDef using the '7700?kcal?kg-1 rule'. Results: Changes in weight (-18.6ᵮ0?kg), FM (-15.5ᴮ3?kg) and FFM (-3.1ᱮ9?kg) did not differ between genders. Measured weight loss was on average 67% of the predicted value, but ranged from 39% to 94%. Relative EDef was correlated with the decrease in RMR (R=0.70, P<0.01), and the decrease in RMR correlated with the difference between actual and expected weight loss (R=0.51, P<0.01). Changes in metabolic rate explained on average 67% of the less-than-expected weight loss, and variability in the proportion of weight lost as FM accounted for a further 5%. On average, after adjustment for changes in metabolic rate and body composition of weight lost, actual weight loss reached 90% of the predicted values. Conclusion: Although weight loss was 33% lower than predicted at baseline from standard energy equivalents, the majority of this differential was explained by physiological variables. Although lower-than-expected weight loss is often attributed to incomplete adherence to prescribed interventions, the influence of baseline calculation errors and metabolic downregulation should not be discounted. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Macmillan Publishers | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 1472 | |
dc.relation.ispartofpageto | 1478 | |
dc.relation.ispartofjournal | International Journal of Obesity | |
dc.relation.ispartofvolume | 36 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Exercise Physiology | |
dc.subject.fieldofresearch | Medical and Health Sciences | |
dc.subject.fieldofresearch | Education | |
dc.subject.fieldofresearchcode | 110602 | |
dc.subject.fieldofresearchcode | 11 | |
dc.subject.fieldofresearchcode | 13 | |
dc.title | Does metabolic compensation explain the majority of less-than-expected weight loss in obese adults during a short-term severe diet and exercise intervention? | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2012 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Hills, Andrew | |