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dc.contributor.authorBecker, S.
dc.contributor.authorBolte, H.
dc.contributor.authorSchunemann, K.
dc.contributor.authorSeitz, H.
dc.contributor.authorBara, J.
dc.contributor.authorBeck-Broichsitter, B.
dc.contributor.authorJ Russo, P.
dc.contributor.authorWiltfang, J.
dc.contributor.authorWarnke, Patrick
dc.date.accessioned2017-05-03T16:10:20Z
dc.date.available2017-05-03T16:10:20Z
dc.date.issued2012
dc.date.modified2013-06-25T00:30:47Z
dc.identifier.issn0901-5027
dc.identifier.doi10.1016/j.ijom.2012.03.031
dc.identifier.urihttp://hdl.handle.net/10072/51863
dc.description.abstractWhen bone morphogenetic protein (BMP) is delivered to matrices in vivo may affect tissue engineered bone constructs for jaw reconstruction after cancer surgery. This study compared the effects of BMP application at different times after matrix implantation for heterotopic bone induction in a rat model. Hydroxyapatite blocks were implanted unilaterally onto the surface of the latissimus dorsi muscle. A second block was implanted onto the contralateral muscle after 1, 2 or 4 weeks and 200 姠rhBMP-2 was injected into the blocks on both sides. Bone formation and density inside the blocks was analysed by CT and histology. 8 weeks after BMP application increases in bone density within the scaffolds were most pronounced in the simultaneous application group (179 HU). Less pronounced increases were observed for the 1 (65 HU), 2 (58 HU) and 4 (31 HU; p<0.0001) week delay group. Homogeneous bone induction started from the central channel of the blocks. Capillaries and larger vessels were seen in all constructs, samples receiving delayed BMP treatment demonstrated significantly greater neovascularization. Delayed application of BMP was less effective for heterotopic bone formation than simultaneous application. A central channel allows homogeneous bone induction directly from the centre of the blocks.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1153
dc.relation.ispartofpageto1160
dc.relation.ispartofissue9
dc.relation.ispartofjournalInternational Journal of Oral and Maxillofacial Surgery
dc.relation.ispartofvolume41
dc.rights.retentionY
dc.subject.fieldofresearchDental Materials and Equipment
dc.subject.fieldofresearchOral and Maxillofacial Surgery
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode110501
dc.subject.fieldofresearchcode110504
dc.subject.fieldofresearchcode1105
dc.titleEndocultivation: the influence of delayed vs. simultaneous application of BMP-2 onto individually formed hydroxyapatite matrices for heterotopic bone induction
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorWarnke, Patrick H.


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