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dc.contributor.authorAnraku, Itaru
dc.contributor.authorRajasuriar, Reena
dc.contributor.authorDobbin, Caroline
dc.contributor.authorBrown, Richard
dc.contributor.authorLewin, Sharon
dc.contributor.authorSuhrbier, Andreas
dc.date.accessioned2018-01-12T00:59:18Z
dc.date.available2018-01-12T00:59:18Z
dc.date.issued2012
dc.date.modified2013-06-27T00:04:41Z
dc.identifier.issn19326203
dc.identifier.doi10.1371/journal.pone.0045291
dc.identifier.urihttp://hdl.handle.net/10072/51990
dc.description.abstractCirculating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome45291-1
dc.relation.ispartofpagetoe45291-4
dc.relation.ispartofissue9
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchcode320499
dc.titleCirculating Heat Shock Protein 60 Levels Are Elevated in HIV Patients and Are Reduced by Anti-Retroviral Therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2012 Anraku et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorSuhrbier, Andreas


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