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dc.contributor.authorPeatey, Christopher
dc.contributor.authorLeroy, Didier
dc.contributor.authorGardiner, Donald
dc.contributor.authorTrenholme, Katharine
dc.date.accessioned2017-08-10T03:12:42Z
dc.date.available2017-08-10T03:12:42Z
dc.date.issued2012
dc.date.modified2013-06-27T00:22:58Z
dc.identifier.issn1475-2875
dc.identifier.doi10.1186/1475-2875-11-34
dc.identifier.urihttp://hdl.handle.net/10072/51999
dc.description.abstractBackground: Recent renewed emphasis on the eradication of malaria has highlighted the need for more tools with which to achieve this ambitious goal. One high priority area is the need to determine the gametocytocidal activity of both currently used anti-malarial drugs and those in the development pipeline. However, testing the activity of compounds against Plasmodium falciparum gametocytes is technically challenging both in vivo and in vitro. Methods: Here the use of a simple robust assay to screen a panel of currently used and experimental anti-malarial drugs against mature P. falciparum gametocytes is described. Results: Eight of 44 compounds tested reduced gametocyte viability by at least 50% and three showed IC50 values in nM range. Conclusions: There is a need to identify new compounds with activity against late stage gametocytes and the information provided by this in vitro assay is a valuable first step, which can guide future clinical studies.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto4
dc.relation.ispartofissue34
dc.relation.ispartofjournalMalaria Journal
dc.relation.ispartofvolume11
dc.rights.retentionY
dc.subject.fieldofresearchMedical Microbiology not elsewhere classified
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical Microbiology
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110899
dc.subject.fieldofresearchcode0605
dc.subject.fieldofresearchcode1108
dc.subject.fieldofresearchcode1117
dc.titleAnti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Peatey et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorGardiner, Donald


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