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  • Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata

    Author(s)
    Feng, Yunjiang
    Bowden, Bruce F
    Kapoor, Vimal
    Griffith University Author(s)
    Feng, Yun J.
    Year published
    2012
    Metadata
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    Abstract
    Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC50 value of 1.5 卮 It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC50 value of 1.5 卮 It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    22
    DOI
    https://doi.org/10.1016/j.bmcl.2012.04.002
    Subject
    Bioinorganic Chemistry
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/52012
    Collection
    • Journal articles

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