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  • Role of Multidrug Resistance Associated Proteins in Drug Development

    Author(s)
    Zhou, Shu-Feng
    Liu, Jun-Ping
    Wei, Ming Qian
    Duan, Wei
    Griffith University Author(s)
    Wei, Ming Q.
    Year published
    2012
    Metadata
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    Abstract
    The Multidrug Resistance Associated Proteins ((MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9) belong to the ATP-binding cassette superfamily (ABCC family) of transporters expressed differentially in the liver, kidney, intestine and blood-brain barrier. MRPs transport a structurally diverse array of endo- and xenobiotics and their metabolites (in particular conjugates) and are subject to induction and inhibition by a variety of compounds. An increased efflux of natural product anticancer drugs and other anticancer agents by MRPs in cancer cells is associated with tumor resistance. These transporting proteins play a ...
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    The Multidrug Resistance Associated Proteins ((MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9) belong to the ATP-binding cassette superfamily (ABCC family) of transporters expressed differentially in the liver, kidney, intestine and blood-brain barrier. MRPs transport a structurally diverse array of endo- and xenobiotics and their metabolites (in particular conjugates) and are subject to induction and inhibition by a variety of compounds. An increased efflux of natural product anticancer drugs and other anticancer agents by MRPs in cancer cells is associated with tumor resistance. These transporting proteins play a role in the absorption, distribution and elimination of various compounds in the body. There are increased reports on the clinical impact of genetic mutations of genes encoding MRP1-9. Therefore, MRPs have an important role in drug development, since a better understanding of their function and regulating mechanism can help minimize and avoid drug toxicity, unfavorable drug-drug interactions, and to overcome drug resistance.
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    Book Title
    Multidrug Resistance: A Global Concern
    Publisher URI
    http://www.benthamscience.com/
    http://www.benthamscience.com/ebooks/9781608052929/
    Subject
    Clinical Pharmacology and Therapeutics
    Pharmacology and Pharmaceutical Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/52101
    Collection
    • Book chapters

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