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dc.contributor.authorZhou, Shu-Feng
dc.contributor.authorLiu, Jun-Ping
dc.contributor.authorWei, Ming Qian
dc.contributor.authorDuan, Wei
dc.contributor.editorKhan, AU
dc.contributor.editorZarrilli, R
dc.date.accessioned2017-05-16T12:32:07Z
dc.date.available2017-05-16T12:32:07Z
dc.date.issued2012
dc.date.modified2013-06-30T23:01:20Z
dc.identifier.isbn978-1-60805-255-4
dc.identifier.urihttp://hdl.handle.net/10072/52101
dc.description.abstractThe Multidrug Resistance Associated Proteins ((MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8 and MRP9) belong to the ATP-binding cassette superfamily (ABCC family) of transporters expressed differentially in the liver, kidney, intestine and blood-brain barrier. MRPs transport a structurally diverse array of endo- and xenobiotics and their metabolites (in particular conjugates) and are subject to induction and inhibition by a variety of compounds. An increased efflux of natural product anticancer drugs and other anticancer agents by MRPs in cancer cells is associated with tumor resistance. These transporting proteins play a role in the absorption, distribution and elimination of various compounds in the body. There are increased reports on the clinical impact of genetic mutations of genes encoding MRP1-9. Therefore, MRPs have an important role in drug development, since a better understanding of their function and regulating mechanism can help minimize and avoid drug toxicity, unfavorable drug-drug interactions, and to overcome drug resistance.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBentham Science Publishers Ltd
dc.publisher.placeNetherlands
dc.publisher.urihttp://www.benthamscience.com/
dc.publisher.urihttp://www.benthamscience.com/ebooks/9781608052929/
dc.relation.ispartofbooktitleMultidrug Resistance: A Global Concern
dc.relation.ispartofchapter1
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3
dc.relation.ispartofpageto35
dc.rights.retentionY
dc.subject.fieldofresearchClinical Pharmacology and Therapeutics
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classified
dc.subject.fieldofresearchcode111502
dc.subject.fieldofresearchcode111599
dc.titleRole of Multidrug Resistance Associated Proteins in Drug Development
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorWei, Ming Q.


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