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  • The influence of varying inspired fractions of O2 and CO2 on the development of involuntary breathing movements during maximal apnoea

    Author(s)
    Breskovic, Toni
    Lojpur, Mihajlo
    Maslov, Petra Zubin
    Cross, Troy J
    Kraljevic, Jasenka
    Ljubkovic, Marko
    Marinovic, Jasna
    Ivancev, Vladimir
    Johnson, Bruce D
    Dujic, Zeljko
    Griffith University Author(s)
    Cross, Troy J.
    Year published
    2012
    Metadata
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    Abstract
    The growing urge to breathe that occurs during breath-holding results in development of involuntary breathing movements (IBMs). The present study determined whether IBMs are initiated at critical levels of hypercapnia and/or hypoxia during maximal apnoea. Arterial blood gasses at the onset of IBM were monitored during maximal voluntary breath-holds. Eleven healthy men performed breath holds after breathing air, hyperoxic-normocapnia, hypoxic-normocapnia, and normoxic-hypercapnia. Pre-breathing of the gas mixtures facilitated the IBM onset, reducing the time-to-onset for ~46% (hyperoxic condition) and for ~80% (hypoxic ...
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    The growing urge to breathe that occurs during breath-holding results in development of involuntary breathing movements (IBMs). The present study determined whether IBMs are initiated at critical levels of hypercapnia and/or hypoxia during maximal apnoea. Arterial blood gasses at the onset of IBM were monitored during maximal voluntary breath-holds. Eleven healthy men performed breath holds after breathing air, hyperoxic-normocapnia, hypoxic-normocapnia, and normoxic-hypercapnia. Pre-breathing of the gas mixtures facilitated the IBM onset, reducing the time-to-onset for ~46% (hyperoxic condition) and for ~80% (hypoxic condition) compared to the normoxic air breathing time. A strong correlation (R = 0.83, P = 0.002) between arterial partial pressure of CO2 (PaCO2PaCO2) at IBM onset after pre-breathing hyperoxic and hypercapnic gas mixtures was observed, suggesting the existence of a possible IBM PaCO2PaCO2 threshold level of ~6.5 ᠰ.5 kPa. No clear "threshold" was observed for partial pressure of arterial O2 (PaO2PaO2). However, we observed that IBM onset was influenced, in part, by an interaction between PaO2PaO2 and PaCO2PaCO2 levels during maximal apnoea. This study demonstrated the complex interaction between arterial blood-gases and the physiological response to maximal breath holding.
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    Journal Title
    Respiratory Physiology and Neurobiology
    Volume
    181
    Issue
    2
    DOI
    https://doi.org/10.1016/j.resp.2012.03.007
    Subject
    Cardiovascular medicine and haematology
    Neurosciences
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/52114
    Collection
    • Journal articles

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