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dc.contributor.authorYang, Yu Rongen_US
dc.contributor.authorK. Ellis, Magdaen_US
dc.contributor.authorP. McManus, Donalden_US
dc.date.accessioned2017-05-03T14:40:07Z
dc.date.available2017-05-03T14:40:07Z
dc.date.issued2012en_US
dc.date.modified2013-06-30T23:16:45Z
dc.identifier.issn14714922en_US
dc.identifier.doi10.1016/j.pt.2012.08.001en_US
dc.identifier.urihttp://hdl.handle.net/10072/52122
dc.description.abstractSusceptibility and resistance to human Echinococcus infection and disease, although poorly understood, appear to reflect a complex interaction of parasite and host immunological and genetic factors. Disease stage, progression, and prognosis following treatment appear to be strongly influenced by cytokine and antibody profiles, and more recent evidence has suggested an important role of dendritic cells (DCs) and T regulatory cells (Tregs) in immunomodulation. Microarrays have supported these findings, highlighting both known and novel pathways involved in chronic murine disease. Genetic studies to date have been few and with limited success. Advanced genomic approaches, such as genome-wide association studies (GWAS), may provide further insight to identify the relevant pathways involved, thereby facilitating a new approach for the development of new clinical therapies.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherElsevier Ltden_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom447en_US
dc.relation.ispartofpageto454en_US
dc.relation.ispartofissue10en_US
dc.relation.ispartofjournalTrends in Parasitologyen_US
dc.relation.ispartofvolume28en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleImmunogenetics of human echinococcosisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Public Healthen_US
gro.date.issued2012
gro.hasfulltextNo Full Text


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