Albopunctatone, an Antiplasmodial Anthrone-Anthraquinone from the Australian Ascidian Didemnum Albopunctatum
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Chemical investigation of a MeOH extract of the Great Barrier Reef ascidian Didemnum albopunctatum has led to the isolation and identification of a new anthrone-anthraquinone, albopunctatone (1), together with the known 1,8-dihydroxy-9,10-anthraquinone (2). The structure of 1 was established from interpretation of 1D and 2D NMR spectroscopic and mass spectrometric data. The compounds were screened for antiplasmodial activity against chloroquine-resistant and -sensitive strains of the malaria parasite, Plasmodium falciparum. Albopunctatone (1) was moderately active against both strains (IC50 5.3 and 4.4 ᠰ.5 卬 respectively), while 2 was inactive at doses up to 40 卮 Both compounds were also inactive up to 40 占when tested against a variety of cancerous and normal human cell lines and the kinetoplastid Trypanosoma brucei brucei, indicating selectivity for the malaria parasite, P. falciparum.
Journal of Natural Products
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Natural Products Chemistry