Show simple item record

dc.contributor.authorGrayson, Jane
dc.contributor.authorBarton, Tom
dc.contributor.authorJ. Cabot, Peter
dc.contributor.authorSouvlis, Tina
dc.date.accessioned2017-05-03T13:51:53Z
dc.date.available2017-05-03T13:51:53Z
dc.date.issued2012
dc.date.modified2013-06-30T23:48:43Z
dc.identifier.issn1356689X
dc.identifier.doi10.1016/j.math.2012.02.004
dc.identifier.urihttp://hdl.handle.net/10072/52165
dc.description.abstractA rapid hypoalgesic effect following spinal manual therapy (SMT) has been demonstrated in humans. Although the characteristics of the pain relief are well described, the mechanisms have remained speculative. The purpose of this suite of studies was to investigate the effects of SMT on pain measures using animal models. This study employed a randomized, controlled design. Study 1: Rats without inflammation were allocated to either a treatment group (n 젶) that received three applications of joint mobilization centrally over L5 or a sham-treated group (n 젶) who received non-specific handling. Pressure pain threshold (PPT) and thermal pain threshold (TPT) were measured before and immediately after each intervention. Results demonstrated significantly increased mechanical nociceptive thresholds in the SMT group (p 젰.01) compared to that of the sham-treated group but no difference for thermal nociceptive thresholds. Study 2: The time course effect of an inflammatory and mechanical response following i.pl injection of inflammatory mediators was investigated to determine the appropriate time period for a treatment intervention. Study 3: The effects of SMT on mechanical nociception were investigated following interplanar injection of inflammatory mediators into the right hind paw of rats as a pain model (n 젶 for both SMT and sham-treated groups). Injection of endogenous metabolites produced significant swelling and flaring as well as increased PPT values following SMT (p < 0.02) compared with controls. These results demonstrate a rapid analgesic response following application of SMT, which has similar characteristics as that seen in both symptomatic and asymptomatic human populations.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom292
dc.relation.ispartofpageto297
dc.relation.ispartofissue4
dc.relation.ispartofjournalManual Therapy
dc.relation.ispartofvolume17
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.titleSpinal manual therapy produces rapid onset analgesia in a rodent model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Rehabilitation Sciences
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorGrayson, Jane


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record