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dc.contributor.authorTizzard, A
dc.contributor.authorWebber, J
dc.contributor.authorGooneratne, R
dc.contributor.authorJohn, R
dc.contributor.authorHay, J
dc.contributor.authorPasco, N
dc.contributor.editorA Townshend, L Buydens, Liang Li, P J Worsfold, P K Dasgupta, P R Haddad, R P Baldwin, U J Krull
dc.date.accessioned2017-05-03T11:26:54Z
dc.date.available2017-05-03T11:26:54Z
dc.date.issued2004
dc.identifier.issn0003-2670
dc.identifier.doi10.1016/j.aca.2004.05.010
dc.identifier.urihttp://hdl.handle.net/10072/5240
dc.description.abstractLincoln Technology has developed a rapid biosensor-based assay called MICREDOX. While MICREDOX was originally developed for biochemical oxygen demand (BOD) monitoring, we now report on how this rapid assay has been extended to perform the direct toxicity assessment (DTA) of toxic chemicals on biological materials resident in the environment. The results show that microelectrode amperometry can adequately replace bulk electrolysis as a detection method. The correlation of these two methods is linear with a good fit (r2 = 0.97). Microelectrode amperometry facilitates the collection of time-course information and the development of toxicity profiles in analyte volumes less than one ml. The response of three bacteria (Bacillus subtilis B8, Escherichia coli K12 and Pseudomonas putida mt-2) to 3,5-dichlorophenol was examined using this revised methodology. EC50 values of 7.5 mg l-1 for B. subtilis, 7.0 mg l-1 for E. coli and 8.0 mg l-1 for P. putida were determined and are in line with EC50 values reported in the literature.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom197
dc.relation.ispartofpageto205
dc.relation.ispartofedition2004
dc.relation.ispartofissue2
dc.relation.ispartofjournalAnalytica Chimica Acta
dc.relation.ispartofvolume522
dc.subject.fieldofresearchAnalytical chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchHistory, heritage and archaeology
dc.subject.fieldofresearchcode3401
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode43
dc.titleMICREDOX: application for rapid biotxicity assessment
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-02-06T01:35:25Z
gro.hasfulltextNo Full Text
gro.griffith.authorJohn, Richard


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