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  • Role of receptor transactivation in the cardioprotective effects of preconditioning and postconditioning

    Author(s)
    Maslov, LN
    Headrick, JP
    Mechoulam, R
    Krylatov, AV
    Lishmanov, AI
    Barzakh, EI
    Naruzhnaia, NV
    Zhang, Y
    Griffith University Author(s)
    Headrick, John P.
    Year published
    2012
    Metadata
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    Abstract
    Analysis of published data indicates that the activity of receptors for adenosine, opioids, bradykinin, calcitonin-gene related peptides (CGRP) and epidermal growth factor (EGF) play important role in triggering the cardioprotective effects of ischemic preconditioning. Cannabinoids mimic the infarct-sparing effects of preconditioning. Endogenous adenosine, opioids, bradykinin and CGRP have also been implicated in infarct-reduction with ischemic postconditioning. Again, cannabinoids also mimic the protective effect of postconditioning. Recent works support heterodimerization of G-protein coupled receptors (GPCRs), and GPCR ...
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    Analysis of published data indicates that the activity of receptors for adenosine, opioids, bradykinin, calcitonin-gene related peptides (CGRP) and epidermal growth factor (EGF) play important role in triggering the cardioprotective effects of ischemic preconditioning. Cannabinoids mimic the infarct-sparing effects of preconditioning. Endogenous adenosine, opioids, bradykinin and CGRP have also been implicated in infarct-reduction with ischemic postconditioning. Again, cannabinoids also mimic the protective effect of postconditioning. Recent works support heterodimerization of G-protein coupled receptors (GPCRs), and GPCR transactivation of EGF receptors. It was found that cross-talk between delta(j)-opioid receptors and adenosine A(1)-receptors is essential to cardiac protection. Furthermore, evidence implicates EGF receptor transactivation in cardioprotective effect of multiple GPCrs including adenosine, acetylcholine, bradykinin, and opioid receptors. Such findings support a convergent pathway in which multiple GPCRs may interact (or function independently) to transactivate EGF receptor-dependent kinase signaling and cytoprotection.
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    Journal Title
    Rossiĭskii Fiziologicheskiĭ Zhurnal imeni I.M. Sechenova
    Volume
    98
    Issue
    3
    Publisher URI
    http://www.iephb.ru/rjournal.htm
    Subject
    Receptors and Membrane Biology
    Physiology not elsewhere classified
    Cardiorespiratory Medicine and Haematology not elsewhere classified
    Medical Physiology
    Publication URI
    http://hdl.handle.net/10072/52654
    Collection
    • Journal articles

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