Show simple item record

dc.contributor.authorMaslov, LN
dc.contributor.authorHeadrick, JP
dc.contributor.authorMechoulam, R
dc.contributor.authorKrylatov, AV
dc.contributor.authorLishmanov, AI
dc.contributor.authorBarzakh, EI
dc.contributor.authorNaruzhnaia, NV
dc.contributor.authorZhang, Y
dc.date.accessioned2018-03-26T01:30:47Z
dc.date.available2018-03-26T01:30:47Z
dc.date.issued2012
dc.date.modified2013-08-20T00:04:46Z
dc.identifier.issn0869-8139
dc.identifier.urihttp://hdl.handle.net/10072/52654
dc.description.abstractAnalysis of published data indicates that the activity of receptors for adenosine, opioids, bradykinin, calcitonin-gene related peptides (CGRP) and epidermal growth factor (EGF) play important role in triggering the cardioprotective effects of ischemic preconditioning. Cannabinoids mimic the infarct-sparing effects of preconditioning. Endogenous adenosine, opioids, bradykinin and CGRP have also been implicated in infarct-reduction with ischemic postconditioning. Again, cannabinoids also mimic the protective effect of postconditioning. Recent works support heterodimerization of G-protein coupled receptors (GPCRs), and GPCR transactivation of EGF receptors. It was found that cross-talk between delta(j)-opioid receptors and adenosine A(1)-receptors is essential to cardiac protection. Furthermore, evidence implicates EGF receptor transactivation in cardioprotective effect of multiple GPCrs including adenosine, acetylcholine, bradykinin, and opioid receptors. Such findings support a convergent pathway in which multiple GPCRs may interact (or function independently) to transactivate EGF receptor-dependent kinase signaling and cytoprotection.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageRussian
dc.language.isorus
dc.publisherSankt-Peterburgskaya Izdatel'skaya Firma Nauka
dc.publisher.placeRussian Federation
dc.publisher.urihttp://www.iephb.ru/rjournal.htm
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom305
dc.relation.ispartofpageto317
dc.relation.ispartofissue3
dc.relation.ispartofjournalRossiĭskii Fiziologicheskiĭ Zhurnal imeni I.M. Sechenova
dc.relation.ispartofvolume98
dc.rights.retentionN
dc.subject.fieldofresearchReceptors and Membrane Biology
dc.subject.fieldofresearchPhysiology not elsewhere classified
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology not elsewhere classified
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode060110
dc.subject.fieldofresearchcode060699
dc.subject.fieldofresearchcode110299
dc.subject.fieldofresearchcode1116
dc.titleRole of receptor transactivation in the cardioprotective effects of preconditioning and postconditioning
dc.title.alternativeRole of receptor transactivation in the cardioprotective effects of preconditioning and postconditioning
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorHeadrick, John P.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record