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dc.contributor.authorJaneczek, Paulina
dc.contributor.authorLewohl, Joanne M
dc.date.accessioned2017-05-03T11:36:58Z
dc.date.available2017-05-03T11:36:58Z
dc.date.issued2013
dc.date.modified2013-08-28T22:17:42Z
dc.identifier.issn0197-0186
dc.identifier.doi10.1016/j.neuint.2013.06.007
dc.identifier.urihttp://hdl.handle.net/10072/52758
dc.description.abstractAlcoholism has complex etiology and there is evidence for both genetic and environmental factors in its pathophysiology. Chronic, long-term alcohol abuse and alcohol dependence are associated with neuronal loss with the prefrontal cortex being particularly susceptible to neurotoxic damage. This brain region is involved in the development and persistence of alcohol addiction and neurotoxic damage is likely to exacerbate the reinforcing effects of alcohol and may hinder treatment. Understanding the mechanism of alcohol's neurotoxic effects on the brain and the genetic risk factors associated with alcohol abuse are the focus of current research. Because of its well-established role in neurodegenerative and neuropsychological disorders, and its emerging role in the pathophysiology of addiction, here we review the genetic and epigenetic factors involved in regulating a-synuclein expression and its potential role in the pathophysiology of chronic alcohol abuse. Elucidation of the mechanisms of a-synuclein regulation may prove beneficial in understanding the role of this key synaptic protein in disease and its potential for therapeutic modulation in the treatment of substance use disorders as well as other neurodegenerative diseases.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1048479 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom154
dc.relation.ispartofpageto162
dc.relation.ispartofissue3
dc.relation.ispartofjournalNeurochemistry International
dc.relation.ispartofvolume63
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchGene expression (incl. microarray and other genome-wide approaches)
dc.subject.fieldofresearchNeurogenetics
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCentral nervous system
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310505
dc.subject.fieldofresearchcode310511
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320903
dc.titleThe role of α-synuclein in the pathophysiology of alcoholism
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorLewohl, Joanne M.


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