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  • How Tumours Escape Mass Destruction

    Author(s)
    Stewart, T.
    Abrams, S.
    Griffith University Author(s)
    Stewart, Trina
    Year published
    2008
    Metadata
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    Abstract
    It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host immunosurveillance and neoplastic progression is revealed in cases where the immune response becomes compromised due to genetic or other pathological conditions, resulting in a substantially increased incidence and rate ofspont aneous tumour formation in both preclinical animal models and patients. It has also been demonstrated in tumour-bearing hosts that the tumorigenic process itselfcan promote a state ofimm unosuppression that, in turn, facilitates neoplastic ...
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    It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host immunosurveillance and neoplastic progression is revealed in cases where the immune response becomes compromised due to genetic or other pathological conditions, resulting in a substantially increased incidence and rate ofspont aneous tumour formation in both preclinical animal models and patients. It has also been demonstrated in tumour-bearing hosts that the tumorigenic process itselfcan promote a state ofimm unosuppression that, in turn, facilitates neoplastic progression. The ability ofne oplastic populations to induce a hostile microenvironment through both cell contact-dependent and -independent immunosuppressive networks is a significant barrier to effective cellmediated immunity and immunotherapy. Thus, a competent immune system is integral for the control of neoplastic disease, and dissecting the plethora oftum our escape mechanisms that disrupt this essential host defense capability is integral for the development of effective immunotherapeutic paradigms.
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    Journal Title
    Oncogene
    Volume
    27
    DOI
    https://doi.org/10.1038/onc.2008.268
    Subject
    Tumour Immunology
    Clinical Sciences
    Oncology and Carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/52826
    Collection
    • Journal articles

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