The Frequency of Malaria Is Similar among Women   Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment

Skinner-Adams, Tina S; Butterworth, Alice S; Porter, Kimberly A; D'Amico, Ronald; Sawe, Fred; Shaffer, Doug; Siika, Abraham; Hosseinipour, Mina C; Stringer, Elizabeth; Currier, Judith S; Chipato, Tsungai; Salata, Robert; Lockman, Shahin; Eron, Joseph J; Meshnick, Steven R; McCarthy, James S

doi:10.1371/journal.pone.0034399

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Author(s)

Skinner-Adams, Tina S

Butterworth, Alice S

Porter, Kimberly A

D'Amico, Ronald

Sawe, Fred

Shaffer, Doug

Siika, Abraham

Hosseinipour, Mina C

Stringer, Elizabeth

Currier, Judith S

Chipato, Tsungai

Salata, Robert

Lockman, Shahin

Eron, Joseph J

Meshnick, Steven R

McCarthy, James S

Griffith University Author(s)

Skinner-Adams, Tina

Year published

2012

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Abstract

HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodium falciparum histidine-rich protein 2 antigen test, among 444 HIV-infected women initiating antiretroviral treatment (ART) in the OCTANE trial (A5208; ClinicalTrials.gov: NCT00089505). Participants were randomized to treatment with PI-containing vs. PI-sparing ART, and were followed prospectively for =48 weeks; 73% also received ...
View more >HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodium falciparum histidine-rich protein 2 antigen test, among 444 HIV-infected women initiating antiretroviral treatment (ART) in the OCTANE trial (A5208; ClinicalTrials.gov: NCT00089505). Participants were randomized to treatment with PI-containing vs. PI-sparing ART, and were followed prospectively for =48 weeks; 73% also received cotrimoxazole prophylaxis. PI-containing treatment was not associated with protection against malaria in this study population.
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