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dc.contributor.authorFailes, Timothy W
dc.contributor.authorBattle, Andrew R
dc.contributor.authorChen, Catherine
dc.contributor.authorCullinane, Carleen
dc.contributor.authorWoods, Ross
dc.contributor.authorElliott, Robyn
dc.contributor.authorDeacon, Glen B
dc.contributor.authorHambley, Trevor W
dc.date.accessioned2017-05-03T16:04:27Z
dc.date.available2017-05-03T16:04:27Z
dc.date.issued2012
dc.date.modified2013-09-12T00:18:46Z
dc.identifier.issn0162-0134
dc.identifier.doi10.1016/j.jinorgbio.2012.04.010
dc.identifier.urihttp://hdl.handle.net/10072/53115
dc.description.abstractCo-crystallisation of diphenyl phosphate (Hdpp) with anticancer active Pt(IV) complexes of the type cis,trans,cis-[PtCl2(OH)2(am(m)ine)2] has produced a new type of supramolecular adduct with short hydrogen bonds from the Hdpp molecules to the hydroxide ligands in all cases. X-ray crystallographic analysis showed within the adduct cis,trans-[PtCl2(en)(OH2)2](dpp)2 (1) a hydrogen bond length of 2.341(6) Å; the shortest O ··· O distance reported in the literature. Similar, though longer hydrogen bonds were observed in three other complexes: [PtCl2(OH)(NH3)2(OH2)]dpp·3H2O (2), trans-[Pt(mal)(OH)(OH2)(S,S-chxn)]dpp·3H2O (3), and trans-[Pt(ox)(OH)(OH2)(S,S-chxn)]dpp·2H2O (4). Co‐crystallisation with Hdpp leads to higher aqueous solubility than the parent complexes indicating the potential of the adducts for use as active pharmaceutical ingredients. Anticancer testing of [Pt(mal)(OH)(OH2)(S,S-chxn)]dpp·3H2O (3) showed in vitro cytotoxicity is low, as expected for Pt(IV) prodrugs, yet substantial tumour growth inhibition was observed in an in vivo ADJ/PC6 tumour model, with activity retained at maximum tolerated dose (MTD)/2 and MTD/4.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom220
dc.relation.ispartofpageto225
dc.relation.ispartofjournalJournal of Inorganic Biochemistry
dc.relation.ispartofvolume115
dc.rights.retentionY
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchBioinorganic chemistry
dc.subject.fieldofresearchTheoretical and computational chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode340201
dc.subject.fieldofresearchcode3407
dc.subject.fieldofresearchcode3499
dc.titleStructural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: The importance of pKa matching
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorBattle, Andrew


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