dc.contributor.author | Failes, Timothy W | |
dc.contributor.author | Battle, Andrew R | |
dc.contributor.author | Chen, Catherine | |
dc.contributor.author | Cullinane, Carleen | |
dc.contributor.author | Woods, Ross | |
dc.contributor.author | Elliott, Robyn | |
dc.contributor.author | Deacon, Glen B | |
dc.contributor.author | Hambley, Trevor W | |
dc.date.accessioned | 2017-05-03T16:04:27Z | |
dc.date.available | 2017-05-03T16:04:27Z | |
dc.date.issued | 2012 | |
dc.date.modified | 2013-09-12T00:18:46Z | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2012.04.010 | |
dc.identifier.uri | http://hdl.handle.net/10072/53115 | |
dc.description.abstract | Co-crystallisation of diphenyl phosphate (Hdpp) with anticancer active Pt(IV) complexes of the type cis,trans,cis-[PtCl2(OH)2(am(m)ine)2] has produced a new type of supramolecular adduct with short hydrogen bonds from the Hdpp molecules to the hydroxide ligands in all cases. X-ray crystallographic analysis showed within the adduct cis,trans-[PtCl2(en)(OH2)2](dpp)2 (1) a hydrogen bond length of 2.341(6) Å; the shortest O ··· O distance reported in the literature. Similar, though longer hydrogen bonds were observed in three other complexes: [PtCl2(OH)(NH3)2(OH2)]dpp·3H2O (2), trans-[Pt(mal)(OH)(OH2)(S,S-chxn)]dpp·3H2O (3), and trans-[Pt(ox)(OH)(OH2)(S,S-chxn)]dpp·2H2O (4). Co‐crystallisation with Hdpp leads to higher aqueous solubility than the parent complexes indicating the potential of the adducts for use as active pharmaceutical ingredients. Anticancer testing of [Pt(mal)(OH)(OH2)(S,S-chxn)]dpp·3H2O (3) showed in vitro cytotoxicity is low, as expected for Pt(IV) prodrugs, yet substantial tumour growth inhibition was observed in an in vivo ADJ/PC6 tumour model, with activity retained at maximum tolerated dose (MTD)/2 and MTD/4. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 220 | |
dc.relation.ispartofpageto | 225 | |
dc.relation.ispartofjournal | Journal of Inorganic Biochemistry | |
dc.relation.ispartofvolume | 115 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Bioinorganic chemistry | |
dc.subject.fieldofresearch | Theoretical and computational chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 340201 | |
dc.subject.fieldofresearchcode | 3407 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.title | Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: The importance of pKa matching | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2012 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Battle, Andrew | |