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  • Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: Results of a Single-Arm uncontrolled study with one-year follow-up

    Author(s)
    Rabago, David
    Zgierska, Aleksandra
    Fortney, Luke
    Kijowski, Richard
    Mundt, Marlon
    Ryan, Michael
    Grettie, Jessica
    J. Patterson, Jeffrey
    Griffith University Author(s)
    Ryan, Michael
    Year published
    2012
    Metadata
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    Abstract
    Objective: The objective of this study was to determine whether prolotherapy, an injection-based complementary treatment for chronic musculoskeletal conditions, improves pain, stiffness, and function in adults with symptomatic knee osteoarthritis (KOA) compared to baseline status. Design: This was a prospective, uncontrolled study with 1-year follow-up. Setting: The study was conducted in an outpatient setting. Participants: Adults with at least 3 months of symptomatic KOA, recruited from clinical and community settings, participated in the study. Interventions: Participants received extra-articular injections of 15% dextrose ...
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    Objective: The objective of this study was to determine whether prolotherapy, an injection-based complementary treatment for chronic musculoskeletal conditions, improves pain, stiffness, and function in adults with symptomatic knee osteoarthritis (KOA) compared to baseline status. Design: This was a prospective, uncontrolled study with 1-year follow-up. Setting: The study was conducted in an outpatient setting. Participants: Adults with at least 3 months of symptomatic KOA, recruited from clinical and community settings, participated in the study. Interventions: Participants received extra-articular injections of 15% dextrose and intra-articular prolotherapy injections of 25% dextrose at 1, 5, and 9 weeks, with as-needed treatments at weeks 13 and 17. Outcome measures: Primary outcome measure was the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC). Secondary outcome measure was the validated Knee Pain Scale (KPS). Tertiary outcome measure was procedure-related pain severity and participant satisfaction. Results: Thirty-six (36) participants (60Ḯ7 years old, 21 female) with moderate-to-severe KOA received an average of 4.3ᰮ7 prolotherapy injection sessions over a 17-week treatment period and reported progressively improved scores during the 52-week study on WOMAC and KPS measures. Participants reported overall WOMAC score improvement 4 weeks after the first injection session (7.6Ხ4 points, 17.2%), and continued to improve through the 52-week follow-up (15.9Ხ5 points, p<0.001, 36.1%). KPS scores improved in both injected (p<0.001) and uninjected knees (p<0.05). Prescribed low-dose opioid analgesia effectively treated procedure-related pain. Satisfaction was high and there were no adverse events. Female gender, age 46-65 years old, and body-mass index of 25 kg/m2 or less were associated with greater improvement on the WOMAC instrument. Conclusions: In adults with moderate to severe KOA, dextrose prolotherapy may result in safe, significant, sustained improvement of knee pain, function, and stiffness scores. Randomized multidisciplinary effectiveness trials including evaluation of potential disease modification are warranted to further assess the effects of prolotherapy for KOA.
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    Journal Title
    Journal of Alternative & Complementary Medicine: research on paradigm, practice, and policy
    Volume
    18
    Issue
    4
    DOI
    https://doi.org/10.1089/acm.2011.0030
    Subject
    Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
    Complementary and Alternative Medicine not elsewhere classified
    Orthopaedics
    Complementary and Alternative Medicine
    Publication URI
    http://hdl.handle.net/10072/53141
    Collection
    • Journal articles

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