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dc.contributor.authorRabago, David
dc.contributor.authorZgierska, Aleksandra
dc.contributor.authorFortney, Luke
dc.contributor.authorKijowski, Richard
dc.contributor.authorMundt, Marlon
dc.contributor.authorRyan, Michael
dc.contributor.authorGrettie, Jessica
dc.contributor.authorJ. Patterson, Jeffrey
dc.date.accessioned2017-05-03T16:06:27Z
dc.date.available2017-05-03T16:06:27Z
dc.date.issued2012
dc.date.modified2013-09-17T22:40:32Z
dc.identifier.issn10755535
dc.identifier.doi10.1089/acm.2011.0030
dc.identifier.urihttp://hdl.handle.net/10072/53141
dc.description.abstractObjective: The objective of this study was to determine whether prolotherapy, an injection-based complementary treatment for chronic musculoskeletal conditions, improves pain, stiffness, and function in adults with symptomatic knee osteoarthritis (KOA) compared to baseline status. Design: This was a prospective, uncontrolled study with 1-year follow-up. Setting: The study was conducted in an outpatient setting. Participants: Adults with at least 3 months of symptomatic KOA, recruited from clinical and community settings, participated in the study. Interventions: Participants received extra-articular injections of 15% dextrose and intra-articular prolotherapy injections of 25% dextrose at 1, 5, and 9 weeks, with as-needed treatments at weeks 13 and 17. Outcome measures: Primary outcome measure was the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC). Secondary outcome measure was the validated Knee Pain Scale (KPS). Tertiary outcome measure was procedure-related pain severity and participant satisfaction. Results: Thirty-six (36) participants (60Ḯ7 years old, 21 female) with moderate-to-severe KOA received an average of 4.3ᰮ7 prolotherapy injection sessions over a 17-week treatment period and reported progressively improved scores during the 52-week study on WOMAC and KPS measures. Participants reported overall WOMAC score improvement 4 weeks after the first injection session (7.6Ხ4 points, 17.2%), and continued to improve through the 52-week follow-up (15.9Ხ5 points, p<0.001, 36.1%). KPS scores improved in both injected (p<0.001) and uninjected knees (p<0.05). Prescribed low-dose opioid analgesia effectively treated procedure-related pain. Satisfaction was high and there were no adverse events. Female gender, age 46-65 years old, and body-mass index of 25 kg/m2 or less were associated with greater improvement on the WOMAC instrument. Conclusions: In adults with moderate to severe KOA, dextrose prolotherapy may result in safe, significant, sustained improvement of knee pain, function, and stiffness scores. Randomized multidisciplinary effectiveness trials including evaluation of potential disease modification are warranted to further assess the effects of prolotherapy for KOA.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMary Ann Liebert
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom408
dc.relation.ispartofpageto414
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Alternative & Complementary Medicine: research on paradigm, practice, and policy
dc.relation.ispartofvolume18
dc.rights.retentionY
dc.subject.fieldofresearchRegenerative Medicine (incl. Stem Cells and Tissue Engineering)
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classified
dc.subject.fieldofresearchOrthopaedics
dc.subject.fieldofresearchComplementary and Alternative Medicine
dc.subject.fieldofresearchcode100404
dc.subject.fieldofresearchcode110499
dc.subject.fieldofresearchcode110314
dc.subject.fieldofresearchcode1104
dc.titleHypertonic dextrose injections (prolotherapy) for knee osteoarthritis: Results of a Single-Arm uncontrolled study with one-year follow-up
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorRyan, Michael


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