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dc.contributor.authorWang, Yejun
dc.contributor.authorvan der Walt, Anneke
dc.contributor.authorPaine, Mark
dc.contributor.authorKlistorner, Alexander
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorEgan, Gary F
dc.contributor.authorKilpatrick, Trevor J
dc.contributor.authorKolbe, Scott C
dc.date.accessioned2018-01-12T01:14:01Z
dc.date.available2018-01-12T01:14:01Z
dc.date.issued2012
dc.date.modified2013-09-17T23:16:51Z
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0052291
dc.identifier.urihttp://hdl.handle.net/10072/53184
dc.description.abstractMagnetisation transfer ratio (MTR) can reveal the degree of proton exchange between free water and macromolecules and was suggested to be pathological informative. We aimed to investigate changes in optic nerve MTR over 12 months following acute optic neuritis (ON) and to determine whether MTR measurements can predict clinical and paraclinical outcomes at 6 and 12 months. Thirty-seven patients with acute ON were studied within 2 weeks of presentation and at 1, 3, 6 and 12 months. Assessments included optic nerve MTR, retinal nerve fibre layer (RNFL) thickness, multifocal visual evoked potential (mfVEP) amplitude and latency and high (100%) and low (2.5%) contrast letter acuity. Eleven healthy controls were scanned twice four weeks apart for comparison with patients. Patient unaffected optic nerve MTR did not significantly differ from controls at any time-point. Compared to the unaffected nerve, affected optic nerve MTR was significantly reduced at 3 months (mean percentage interocular difference = -9.24%, p = 0.01), 6 months (mean = -12.48%, p<0.0001) and 12 months (mean = -7.61%, p = 0.003). Greater reduction in MTR at 3 months in patients was associated with subsequent loss of high contrast letter acuity at 6 (? = 0.60, p = 0.0003) and 12 (? = 0.44, p = 0.009) months, low contrast letter acuity at 6 (? = 0.35, p = 0.047) months, and RNFL thinning at 12 (? = 0.35, p = 0.044) months. Stratification of individual patient MTR time courses based on flux over 12 months (stable, putative remyelination and putative degeneration) predicted RNFL thinning at 12 months (F2,32 = 3.59, p = 0.02). In conclusion, these findings indicate that MTR flux after acute ON is predictive of axonal degeneration and visual disability outcomes.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome52291 -1
dc.relation.ispartofpagetoe52291 - 7
dc.relation.ispartofissue12
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchcode119999
dc.titleOptic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2012 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.date.issued2012
gro.hasfulltextFull Text
gro.griffith.authorButzkueven, Helmut


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