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  • Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis

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    TrojanoPUB735.PDF (560.7Kb)
    Author(s)
    Trojano, Maria
    Lucchese, Guglielmo
    Graziano, Giusi
    Taylor, Bruce V
    Simpson, Steve
    Lepore, Vito
    Grand'Maison, Francois
    Duquette, Pierre
    Izquierdo, Guillermo
    Grammond, Pierre
    Amato, Maria Pia
    Bergamaschi, Roberto
    Giuliani, Giorgio
    Boz, Cavit
    Hupperts, Raymond
    Van Pesch, Vincent
    Lechner-Scott, Jeannette
    Cristiano, Edgardo
    Fiol, Marcela
    Oreja-Guevara, Celia
    Laura Saladino, Maria
    Verheul, Freek
    Slee, Mark
    Paolicelli, Damiano
    Tortorella, Carla
    D'Onghia, Mariangela
    Iaffaldano, Pietro
    Direnzo, Vita
    Butzkueven, Helmut
    Griffith University Author(s)
    Butzkueven, Helmut
    Year published
    2012
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    Abstract
    Background A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out. Objective In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas. Methods Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ...
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    Background A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out. Objective In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas. Methods Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births. Results Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83ࠎ and 45ࠎ (from 1.93 to 4.55; p<0.0001) and between 45ࠎ to 35ࠎ (from 1.46 to 2.30; p<0.05) latitude, while a sex ratio stability over time was found in the subgroup from areas between 12ࠓ and 55ࠓ latitude. The sex ratio increase mainly affected relapsing-remitting (RR) MS. Conclusions Our results confirm a general sex ratio increase over time in RRMS and also demonstrate a latitudinal gradient of this increase. These findings add useful information for planning case-control studies aimed to explore sex-related factors responsible for MS development.
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    Journal Title
    PLoS ONE
    Volume
    7
    Issue
    10
    DOI
    https://doi.org/10.1371/journal.pone.0048078
    Copyright Statement
    © 2012 Trojano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Subject
    Medical and Health Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/53197
    Collection
    • Journal articles

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