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  • Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis

    Author(s)
    Kolbe, Scott C
    Marriott, Mark
    van der Walt, Anneke
    Fielding, Joanne
    Klistorner, Alexander
    Mitchell, Peter J
    Butzkueven, Helmut
    Kilpatrick, Trevor J
    Egan, Gary F
    Griffith University Author(s)
    Butzkueven, Helmut
    Year published
    2012
    Metadata
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    Abstract
    Purpose. To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). Methods. Twenty-three patients with clinically definite relapsing- remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100%, 2.5%, and 1.25% contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. Results. The MS ...
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    Purpose. To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). Methods. Twenty-three patients with clinically definite relapsing- remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100%, 2.5%, and 1.25% contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. Results. The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5% and 1.25% contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. Conclusions. In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.
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    Journal Title
    Investigative Optamology and Visual Science
    Volume
    53
    Issue
    2
    DOI
    https://doi.org/10.1167/iovs.11-8864
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/53216
    Collection
    • Journal articles

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