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dc.contributor.authorKolbe, Scott C
dc.contributor.authorMarriott, Mark
dc.contributor.authorvan der Walt, Anneke
dc.contributor.authorFielding, Joanne
dc.contributor.authorKlistorner, Alexander
dc.contributor.authorMitchell, Peter J
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorKilpatrick, Trevor J
dc.contributor.authorEgan, Gary F
dc.date.accessioned2017-05-03T14:21:01Z
dc.date.available2017-05-03T14:21:01Z
dc.date.issued2012
dc.date.modified2013-09-17T23:40:45Z
dc.identifier.issn0146-0404
dc.identifier.doi10.1167/iovs.11-8864
dc.identifier.urihttp://hdl.handle.net/10072/53216
dc.description.abstractPurpose. To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). Methods. Twenty-three patients with clinically definite relapsing- remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100%, 2.5%, and 1.25% contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. Results. The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5% and 1.25% contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. Conclusions. In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAssociation for Research in Vision and Ophthalmology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom825
dc.relation.ispartofpageto832
dc.relation.ispartofissue2
dc.relation.ispartofjournalInvestigative Optamology and Visual Science
dc.relation.ispartofvolume53
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.titleDiffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorButzkueven, Helmut


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