Show simple item record

dc.contributor.authorKolbe, Scott C
dc.contributor.authorMarriott, Mark
dc.contributor.authorvan der Walt, Anneke
dc.contributor.authorFielding, Joanne
dc.contributor.authorKlistorner, Alexander
dc.contributor.authorMitchell, Peter J
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorKilpatrick, Trevor J
dc.contributor.authorEgan, Gary F
dc.description.abstractPurpose. To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). Methods. Twenty-three patients with clinically definite relapsing- remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100%, 2.5%, and 1.25% contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. Results. The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5% and 1.25% contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. Conclusions. In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.
dc.publisherAssociation for Research in Vision and Ophthalmology
dc.publisher.placeUnited States
dc.relation.ispartofjournalInvestigative Optamology and Visual Science
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.titleDiffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorButzkueven, Helmut

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record