Show simple item record

dc.contributor.authorRamos, SB
dc.contributor.authorBrenu, EW
dc.contributor.authorChristy, R
dc.contributor.authorGray, B
dc.contributor.authorMcNaughton, L
dc.contributor.authorTajouri, L
dc.contributor.authorVan Driel, M
dc.contributor.authorMarshall-Gradisnik, SM
dc.date.accessioned2017-09-18T12:30:32Z
dc.date.available2017-09-18T12:30:32Z
dc.date.issued2011
dc.date.modified2013-09-19T23:17:53Z
dc.identifier.issn1439-6319
dc.identifier.doi10.1007/s00421-010-1756-4
dc.identifier.urihttp://hdl.handle.net/10072/53258
dc.description.abstractGrowth hormone (GH) is a commonly used drug aimed at improving sport performance. The aim of this study is to evaluate the immunomodulatory effects of short-term administration of recombinant GH (rhGH) in healthy young males. NK cell number, activity and phenotype, T cell number, CD4+ (Th1/Th2) cytokine production of IL2, IL4, IL6, IL10, TNF-a and IFN-? and CD4+/CD8+ ratio with particular attention to the possible correlation to IGF-I production were investigated. 30 males (27 ᠹ years) were randomly assigned to placebo (n = 15) or drug (rhGH) 1 mg/day groups (n = 15) with daily injection for 7 days. IGF-I plasma concentration and flow cytometry data were generated at baseline and days 8, 15, 22 and 29 post injection. Data analysis used General Linear Model with repeated measures, Bonferroni correction factor and significance at p = 0.05. Serum IGF-I levels (ng/mL) increased significantly (p = 0.01) on day 8 (0.48 ᠰ.78) after injections compared to baseline (0.31 ᠰ.07) and days 15 (0.33 ᠰ.06), 22 (0.29 ᠰ.05) and 29 (0.29 ᠰ.06). A significant time effect was noted in IL10 secretion (pg/mL) from day 15 (P = 35.14 ᠱ9.93, rhGH = 26.63 ᠱ6.39) to days 22 (P = 61.32 ᠲ0.41, rhGH = 74.99 ᠴ6.91) and 29 (P = 101.98 ᠶ7.25, rhGH = 107.74; ᠱ22.58). There was no correlation between IGF-I and NK activity, phenotype or number along with T lymphocyte number, CD4+/CD8+ ratio or Th1 and Th2 cytokine production. In conclusion, cytokine secretion spectrum was not affected by short-term rhGH administration in young males.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1307
dc.relation.ispartofpageto1312
dc.relation.ispartofissue7
dc.relation.ispartofjournalEuropean Journal of Applied Physiology
dc.relation.ispartofvolume111
dc.rights.retentionY
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchCellular immunology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode320404
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3208
dc.titleAssessment of immune function after short-term administration of recombinant human growth hormone in healthy young males
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorRamos, Sandra B.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record