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  • Myalgic encephalomyelitis: International Consensus Criteria

    Author(s)
    Carruthers, BM
    van de Sande, MI
    De Meirleir, KL
    Klimas, NG
    Broderick, G
    Mitchell, T
    Staines, D
    Powles, ACP
    Speight, N
    Vallings, R
    Bateman, L
    Baumgarten-Austrheim, B
    Bell, DS
    Carlo-Stella, N
    Chia, J
    Darragh, A
    Jo, D
    Lewis, D
    Light, AR
    Marshall-Gradisbik, S
    Mena, I
    Mikovits, JA
    Miwa, K
    Murovska, M
    Pall, ML
    Stevens, S
    Griffith University Author(s)
    Marshall-Gradisnik, Sonya M.
    Year published
    2011
    Metadata
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    Abstract
    The label 'chronic fatigue syndrome' (CFS) has persisted for many years because of the lack of knowledge of the aetiological agents and the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term 'myalgic encephalomyelitis' (ME) because it indicates an underlying pathophysiology. It is also consistent with the neurological classification of ME in the World Health Organization's International Classification of Diseases (ICD G93.3). Consequently, an International Consensus Panel ...
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    The label 'chronic fatigue syndrome' (CFS) has persisted for many years because of the lack of knowledge of the aetiological agents and the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term 'myalgic encephalomyelitis' (ME) because it indicates an underlying pathophysiology. It is also consistent with the neurological classification of ME in the World Health Organization's International Classification of Diseases (ICD G93.3). Consequently, an International Consensus Panel consisting of clinicians, researchers, teaching faculty and an independent patient advocate was formed with the purpose of developing criteria based on current knowledge. Thirteen countries and a wide range of specialties were represented. Collectively, members have approximately 400 years of both clinical and teaching experience, authored hundreds of peer-reviewed publications, diagnosed or treated approximately 50 000 patients with ME, and several members coauthored previous criteria. The expertise and experience of the panel members as well as PubMed and other medical sources were utilized in a progression of suggestions/drafts/reviews/revisions. The authors, free of any sponsoring organization, achieved 100% consensus through a Delphi-type process. The scope of this paper is limited to criteria of ME and their application. Accordingly, the criteria reflect the complex symptomatology. Operational notes enhance clarity and specificity by providing guidance in the expression and interpretation of symptoms. Clinical and research application guidelines promote optimal recognition of ME by primary physicians and other healthcare providers, improve the consistency of diagnoses in adult and paediatric patients internationally and facilitate clearer identification of patients for research studies.
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    Journal Title
    Journal of Internal Medicine
    Volume
    270
    Issue
    4
    DOI
    https://doi.org/10.1111/j.1365-2796.2011.02428.x
    Subject
    Clinical sciences
    Epidemiology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/53259
    Collection
    • Journal articles

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