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  • Novel pathomechanisms in chronic fatigue syndrome/myalgic encephalomyelitis: do purinergic signalling perturbations and gliosis play a role?

    Author(s)
    Staines, D.
    Brenu, E.
    Marshall-Gradisnik, S.
    Griffith University Author(s)
    Marshall-Gradisnik, Sonya M.
    Brenu, Ekua
    Year published
    2010
    Metadata
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    Abstract
    CFS/ME is, in some cases, a serious fatigue-related condition exhibiting a range of neurological, immunological and metabolic dysfunctions in symptom presentation. The present paper explores the possibility of perturbations of purinergic signalling (PS) as a pathomechanism of CFS/ME involving glial cell dysfunction, disruption of neuronal transmission, neuroinflammation and possible disturbances in the functioning of the blood-brain and blood-spinal barriers (BBB/BSB). This paper discusses the possibility that the putative neuroinflammatory processes may occur through perturbations of PS involving vasoactive neuropeptide ...
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    CFS/ME is, in some cases, a serious fatigue-related condition exhibiting a range of neurological, immunological and metabolic dysfunctions in symptom presentation. The present paper explores the possibility of perturbations of purinergic signalling (PS) as a pathomechanism of CFS/ME involving glial cell dysfunction, disruption of neuronal transmission, neuroinflammation and possible disturbances in the functioning of the blood-brain and blood-spinal barriers (BBB/BSB). This paper discusses the possibility that the putative neuroinflammatory processes may occur through perturbations of PS involving vasoactive neuropeptide (VN) dysfunction (e.g. through autoimmune mechanisms). Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) function as neurotransmitters, vasodilators and regulators of immunity, nociception and hypoxic injury. They are important in the central nervous system (CNS) by activating adenylate cyclase (AC) to produce cAMP from ATP. Compromise of ATP metabolism may promote neuronal and glial toxicity through impaired cAMP production or impaired ATP metabolism and these may alter BBB/BSB function. Although speculative, diagnostic and therapeutic implications may exist for CFS/ME if VN compromise, along with perturbations of PS, do indeed disrupt neurological and glial cell functioning. Treatment opportunities involving phosphodiesterase inhibitors (PDEIs) and purinergic modulators may plausibly exist.
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    Journal Title
    Bulletin of the International Association for Chronic Fatigue Syndrome and Myalgic Encephalomyelitis
    Volume
    18
    Issue
    1
    Publisher URI
    https://www.iacfsme.org/bulletins/
    Subject
    Central Nervous System
    Clinical Sciences
    Human Movement and Sports Sciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/53278
    Collection
    • Journal articles

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