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dc.contributor.authorSirdaarta, Josephen_US
dc.contributor.authorCock, Ian Edwinen_US
dc.date.accessioned2012-08-22en_US
dc.date.accessioned2013-10-16T21:37:10Z
dc.date.accessioned2017-03-01T22:45:28Z
dc.date.available2017-03-01T22:45:28Z
dc.date.issued2012en_US
dc.date.modified2013-10-16T21:37:10Z
dc.identifier.urihttp://hdl.handle.net/10072/53584
dc.description.abstractABSTRACT Introduction: Kakadu Plum (Terminalia ferdinandiana Exell, Combretaceae) is an Australian native plant endemic to the tropical northern regions of Australia. It is known for its extremely high ascorbic acid and antioxidant content. Previous studies indicate that Kakadu plum may have medicinal potential in the treatment of various diseases. This study aimed to investigate its potential to quell free radicals and its role as an anticancer agent. Methods: Dehydrated Kakadu plum fruit were extracted with a variety of solvents and the extracts were dried and resuspended as aqueous solutions. The extracts were tested for their antioxidative potential in established assays. The extracts were also tested in vitro for anticancer activity by exposing a variety of cancer cells and normal cell lines to the extracts and noting cell viability and cell death. Results: Kakadu Plum extracts exhibited substantial anti-oxidative activity, reducing power, superoxide anion scavenging potential, DPPH radical scavenging activity and ability to limit lipid peroxidation in antioxidant assays. Subsequent trials of Kakadu plum extracts against normal cell lines (Hs 738.St/Int, CCD-18Co ect.) and cancer cell lines (AGS, HT-29, HL-60 etc.) were attempted to confirm previous studies. Positive results were noted against all cancer cell lines, yet the normal cells were largely unaffected. The extracts were also tested against a wider panel of cancer cell lines, exhibiting anticancer activity against most cancer cell lines tested. Equally important, the Kakadu plum extracts did not inhibit the viability of any normal cell line tested. Conclusions: Kakadu plum extracts show promise in the treatment of a variety of different types of cancer, yet are non-toxic towards normal cell lines.en_US
dc.description.peerreviewedNoen_US
dc.description.publicationstatusYesen_US
dc.publisher.urihttp://3ismp.bau.edu.jo/en_US
dc.relation.ispartofstudentpublicationYen_US
dc.relation.ispartofconferencename3rd International Symposium on Medicinal Plants, Their Cultivation and Aspects of Usesen_US
dc.relation.ispartofconferencetitle3rd International Symposium on Medicinal Plants, Their Cultivation and Aspects of Usesen_US
dc.relation.ispartofdatefrom2012-11-21en_US
dc.relation.ispartofdateto2012-11-23en_US
dc.relation.ispartoflocationPetra Jordanen_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchBiochemistry and Cell Biologyen_US
dc.subject.fieldofresearchcode060199en_US
dc.titleANTIOXIDANT AND ANTICANCER ACTIVITIES OF TERMINALIA FERDINANDIANA (KAKADU PLUM)en_US
dc.typeConference output
dc.type.descriptionConference Publications (Extract Paper)en_US
dc.type.codee3en_US
gro.facultyFaculty of Science, Environment, Engineering and Technologyen_US
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorP, Joseph S.
gro.griffith.authorCock, Ian E.


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    Contains papers delivered by Griffith authors at national and international conferences.

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