Show simple item record

dc.contributor.authorSt John, James Anthony
dc.contributor.authorEkberg, Jenny A
dc.date.accessioned2012-10-09
dc.date.accessioned2013-10-16T22:10:30Z
dc.date.accessioned2017-03-01T22:45:36Z
dc.date.available2017-03-01T22:45:36Z
dc.date.issued2012
dc.date.modified2013-10-16T22:10:30Z
dc.identifier.urihttp://hdl.handle.net/10072/53602
dc.description.abstractThe glia of the olfactory system, olfactory ensheathing cells (OECs) are excellent candidates for neural repair. In their natural environment within the olfactory system, OECs are present within the peripheral nervous system and the central nervous system and they are considered to be crucial to the ability of olfactory neurons to regenerate throughout life. However, OECs are not a uniform population. Instead there are different subpopulations, each with a different molecular profile and proposed role in vivo. If OECs are to be used for neural repair therapies, it is therefore important to consider the different characteristics of the various subpopulations of OECs and their potential therapeutic benefit. Using in vitro assays, we have determined that OECs derived from the peripheral nervous system in the nasal cavity respond differently to OECs isolated from the olfactory bulb in the central nervous system. Peripheral OECs are a uniform population that predominantly adhere to each and thereby promote contact-mediated migration of each other. In contrast, OECs from the olfactory bulb are a heterogeneous population that exhibit differential preference for contact with each other and are less likely to promote contact-mediated migration. We have further purified OECs from distinct anatomical regions of the olfactory bulb and used cell behaviour assays to reveal that OECs obtained from the rostral, ventral, dorsal and caudal regions of the olfactory bulb all exhibit strikingly different behaviours during cell-cell contact. The behaviours of the different subpopulations of OECs are consistent with their proposed roles in vivo. We found that the heterogeneity of the OECs is regulated by motile lamellipodial waves and that inhibition of the lamellipodial wave activity abolishes the ability of the cells to distinguish between each other. These results demonstrate that individual subpopulations of OECs with distinct properties exist within the olfactory nervous system. These results have important implications for selecting the source of OECs for neural transplant therapies.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.publisher.urihttp://www.bitlifesciences.com/rmsc2012/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameBIT's 5th Annual World Congress of Regenerative Medicine and Stem Cell 2012
dc.relation.ispartofconferencetitleProceedings of the BIT's 5th Annual World Congress of Regenerative Medicine and Stem Cell 2012
dc.relation.ispartofdatefrom2012-12-02
dc.relation.ispartofdateto2012-12-04
dc.relation.ispartoflocationGuangzhou, China
dc.rights.retentionY
dc.subject.fieldofresearchPeripheral Nervous System
dc.subject.fieldofresearchCentral Nervous System
dc.subject.fieldofresearchcode110905
dc.subject.fieldofresearchcode110903
dc.titleThe therapeutic potential of subpopulations of olfactory glia for neural repair
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codee3
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.date.issued2012
gro.hasfulltextNo Full Text
gro.griffith.authorSt John, James A.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Conference outputs
    Contains papers delivered by Griffith authors at national and international conferences.

Show simple item record