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dc.contributor.authorC.M. Cheung, Leo
dc.contributor.authorK. Y. Lai, Kenneth
dc.contributor.authorLam, Alfred
dc.contributor.authorC. O. Tang, Johnny
dc.contributor.authorM. Luk, John
dc.contributor.authorP. Lee, Nikki
dc.contributor.authorChung, Yvonne
dc.contributor.authorK. H. Tong, Daniel
dc.contributor.authorLaw, Simon
dc.date.accessioned2017-05-03T16:03:21Z
dc.date.available2017-05-03T16:03:21Z
dc.date.issued2013
dc.date.modified2013-11-11T22:14:42Z
dc.identifier.issn2231-0614
dc.identifier.urihttp://hdl.handle.net/10072/54154
dc.description.abstractBackground: Esophageal cancer is one of the most deadly malignancies worldwide and esophageal squamous cell carcinoma (ESCC) is the most frequent type. Methods: We identified up-regulated genes from gene expression profiles of HKESC-4 cell line, its parental tumor tissues, non-tumoral esophageal epithelia and lymph nodes with metastatic carcinoma using Human Genome U133 Plus 2.0 microarray. Results: Four genes [High-mobility group AT-hook 2 (HMGA2), paternally expressed 10 (PEG10), SH3 and multiple ankyrin repeat domains 2 (SHANK2) and WNT1 inducible signaling pathway protein 3 (WISP3)] were selected for further validation with real-time quantitative polymerase chain reaction (qPCR) in a panel of ESCC cell lines and clinical specimens. HMGA2 was found to be overexpressed in the panel of ESCC cell lines tested. By using immunohistochemistry, HMGA2 was found to be up-regulated in 70% of ESCC tissues (21 out of 30 cases). Conclusion: This study demonstrates successful use of gene microarray to identify and reveal HMGA2 as a novel and consistently overexpressed gene in ESCC cell lines and clinical samples. - See more at: http://www.sciencedomain.org/abstract.php?iid=177&id=12&aid=963#.UoAhmCdQga8
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1085191 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherScienceDomain International
dc.publisher.placeIndia
dc.publisher.urihttp://www.sciencedomain.org/abstract.php?iid=177&id=12&aid=963#.UoAhmCdQga8
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom407
dc.relation.ispartofpageto419
dc.relation.ispartofissue2
dc.relation.ispartofjournalBritish Journal of Medicine and Medical Research
dc.relation.ispartofvolume3
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchcode119999
dc.titleGene Expression Profiling Identified Highmobility Group AT-hook 2 (HMGA2) as Being Frequently Upregulated in Esophageal Squamous Cell Carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/
gro.rights.copyright© The Author(s) 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.


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