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dc.contributor.authorSanthakumar, Abisheken_US
dc.contributor.authorFozzard, Nikkien_US
dc.contributor.authorPerkins, Anthonyen_US
dc.contributor.authorSingh, Induen_US
dc.date.accessioned2019-01-07T01:31:00Z
dc.date.available2019-01-07T01:31:00Z
dc.date.issued2013en_US
dc.date.modified2013-11-11T22:35:24Z
dc.identifier.issn21629412en_US
dc.identifier.urihttp://hdl.handle.net/10072/54185
dc.description.abstractSeveral studies have shown the deleterious effects of energy drinks, containing taurine and caffeine, on cardiac health. This study aimed to examine synergistic effect of taurine and caffeine on platelets and haemostasis because platelet hyperactivity is a known predictor of cardiovascular diseases. Blood from twelve healthy volunteers aged 18 - 60 years was incubated with 500 占taurine and 700 占caffeine individually or together. Platelet activity was evaluated using platelet aggregation assays induced by ADP and collagen, and, haemostatic function by coagulation profile testing, glucose, lipid profile and inflammation marker C- reactive protein assessment (CRP). The optimal time and doses of taurine and caffeine required to inhibit platelet hyperactivity in vitro were established. A combined action of lower doses of taurine and caffeine (T+C) inhibited platelet aggregation, induced by ADP and collagen, greater than taurine or caffeine individually (p < 0.05). Taurine and T+C increased prothrombin clotting time (PT) significantly (p < 0.05), while caffeine alone decreased PT (p < 0.05). Caffeine alone increased CRP (p < 0.05). No significant change was observed in lipid parameters. These data support our hypothesis that, synergistically lower concentrations of taurine and caffeine, found in much higher concentrations in energy drinks, may be instrumental in reducing platelet activity and prolongation of clot formation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent255264 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherScientific & Academic Publishingen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://article.sapub.org/10.5923.j.fph.20130303.06.htmlen_US
dc.relation.ispartofstudentpublicationYen_US
dc.relation.ispartofpagefrom147en_US
dc.relation.ispartofpageto153en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalFood and Public Healthen_US
dc.relation.ispartofvolume3en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCardiovascular Medicine and Haematology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110299en_US
dc.titleThe Synergistic Effect of Taurine and Caffeine on Platelet Activity and Hemostatic Functionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyright© 2013 Scientific & Academic Publishing. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2013
gro.hasfulltextFull Text


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