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dc.contributor.authorBulmer, AC
dc.contributor.authorVerkade, HJ
dc.contributor.authorWagner, K-H
dc.date.accessioned2017-05-03T15:40:15Z
dc.date.available2017-05-03T15:40:15Z
dc.date.issued2013
dc.date.modified2013-11-11T22:45:25Z
dc.identifier.issn0163-7827
dc.identifier.doi10.1016/j.plipres.2012.11.001
dc.identifier.urihttp://hdl.handle.net/10072/54228
dc.description.abstractGilbert's syndrome (GS) is characterized by a benign, mildly elevated bilirubin concentration in the blood. Recent reports show clear protection from cardiovascular disease in this population. Protection of lipids, proteins and other macromolecules from oxidation by bilirubin represents the most commonly accepted mechanism contributing to protection in this group. However, a recent meta-analysis estimated that bilirubin only accounts for ~34% of the cardioprotective effects within analysed studies. To reveal the additional contributing variables we have explored circulating cholesterol and triacylglycerol concentrations, which appear to be decreased in hyperbilirubinemic individuals/animals, and are accompanied by lower body mass index in highly powered studies. These results suggest that bilirubin could be responsible for the development of a lean and hypolipidemic state in GS. Here we also discuss the possible contributing mechanisms that might reduce circulating cholesterol and triacylglycerol concentrations in individuals with syndromes affecting bilirubin metabolism/excretion, which we hope will stimulate future research in the area. In summary, this article is the first review of lipid status in animal and human studies of hyperbilirubinemia and explores possible mechanisms that could contribute to lowering circulating lipid parameters and further explain cardiovascular protection in Gilbert's syndrome.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent992152 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom193
dc.relation.ispartofpageto205
dc.relation.ispartofissue2
dc.relation.ispartofjournalProgress in Lipid Research
dc.relation.ispartofvolume52
dc.rights.retentionY
dc.subject.fieldofresearchCardiology (incl. Cardiovascular Diseases)
dc.subject.fieldofresearchGastroenterology and Hepatology
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchcode110201
dc.subject.fieldofresearchcode110307
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.subject.fieldofresearchcode1111
dc.titleBilirubin and beyond: A review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2013 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2013
gro.hasfulltextFull Text
gro.griffith.authorBulmer, Andrew C.
gro.griffith.authorWagner, Karl-Heinz


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